The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework

Antoine Tacheau, Simon Le Floc'h, Gérard Finet, Marvin M. Doyley, Roderic I. Pettigrew, Guy Cloutier, Jacques Ohayon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.

Original languageEnglish (US)
Pages (from-to)727-741
Number of pages15
JournalUltrasound in Medicine and Biology
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Coronary disease
  • Elastography
  • Inverse problem
  • Linear elasticity
  • Modulography
  • Vulnerable plaques

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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