The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework

Antoine Tacheau; Simon Le Floc'h; Gérard Finet; Marvin M. Doyley; Roderic I. Pettigrew; Guy Cloutier; Jacques Ohayon

doi:10.1016/j.ultrasmedbio.2015.11.015

The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework

Antoine Tacheau, Simon Le Floc'h, Gérard Finet, Marvin M. Doyley, Roderic I. Pettigrew, Guy Cloutier, Jacques Ohayon

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.

Original language	English (US)
Pages (from-to)	727-741
Number of pages	15
Journal	Ultrasound in Medicine and Biology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2015.11.015
State	Published - Mar 1 2016

Keywords

Coronary disease
Elastography
Inverse problem
Linear elasticity
Modulography
Vulnerable plaques

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2015.11.015

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title = "The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework",

abstract = "Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.",

keywords = "Coronary disease, Elastography, Inverse problem, Linear elasticity, Modulography, Vulnerable plaques",

author = "Antoine Tacheau and {Le Floc'h}, Simon and G{\'e}rard Finet and Doyley, {Marvin M.} and Pettigrew, {Roderic I.} and Guy Cloutier and Jacques Ohayon",

note = "Funding Information: This research was supported by a joint international program of the Agence Nationale de la Recherche (ANR) grant MELANII project #09-BLAN-0423 and of the of the Natural Sciences and Engineering Research Council of Canada (NSERC) strategic grant #STPGP-381136-09. Partial support was provided by NSERC discovery grant #138570-11. The authors thank Dr. Flavien Deleaval (TIMC Laboratory, Grenoble) for computational support and Dr Saami K. Yazdani (Department of Mechanical Engineering, University of South Alabama, Mobile, AL, USA) for helpful discussions. Antoine Tacheau held a doctoral fellowship from University Grenoble-Alpes, France (AGIR 2013). Publisher Copyright: {\textcopyright} 2016 World Federation for Ultrasound in Medicine & Biology.",

year = "2016",

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doi = "10.1016/j.ultrasmedbio.2015.11.015",

language = "English (US)",

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T1 - The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound

T2 - Theoretical Framework

AU - Tacheau, Antoine

AU - Le Floc'h, Simon

AU - Finet, Gérard

AU - Doyley, Marvin M.

AU - Pettigrew, Roderic I.

AU - Cloutier, Guy

AU - Ohayon, Jacques

N1 - Funding Information: This research was supported by a joint international program of the Agence Nationale de la Recherche (ANR) grant MELANII project #09-BLAN-0423 and of the of the Natural Sciences and Engineering Research Council of Canada (NSERC) strategic grant #STPGP-381136-09. Partial support was provided by NSERC discovery grant #138570-11. The authors thank Dr. Flavien Deleaval (TIMC Laboratory, Grenoble) for computational support and Dr Saami K. Yazdani (Department of Mechanical Engineering, University of South Alabama, Mobile, AL, USA) for helpful discussions. Antoine Tacheau held a doctoral fellowship from University Grenoble-Alpes, France (AGIR 2013). Publisher Copyright: © 2016 World Federation for Ultrasound in Medicine & Biology.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.

AB - Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.

KW - Coronary disease

KW - Elastography

KW - Inverse problem

KW - Linear elasticity

KW - Modulography

KW - Vulnerable plaques

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SN - 0301-5629

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ER -

The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework

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Keywords

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