The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Christine M. Disteche; Camilynn I. Brannan; Alf Larsen; David A. Adler; Daniel F. Schorderet; David Gearing; Neal G. Copeland; Nancy A. Jenkins; Linda S. Park

doi:10.1038/ng0892-333

The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Christine M. Disteche, Camilynn I. Brannan, Alf Larsen, David A. Adler, Daniel F. Schorderet, David Gearing, Neal G. Copeland, Nancy A. Jenkins, Linda S. Park

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Abstract

The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

Original language	English (US)
Pages (from-to)	333-336
Number of pages	4
Journal	Nature Genetics
Volume	1
Issue number	5
DOIs	https://doi.org/10.1038/ng0892-333
State	Published - Aug 1992

ASJC Scopus subject areas

Genetics

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title = "The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse",

abstract = "The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.",

author = "Disteche, \{Christine M.\} and Brannan, \{Camilynn I.\} and Alf Larsen and Adler, \{David A.\} and Schorderet, \{Daniel F.\} and David Gearing and Copeland, \{Neal G.\} and Jenkins, \{Nancy A.\} and Park, \{Linda S.\}",

year = "1992",

month = aug,

doi = "10.1038/ng0892-333",

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T1 - The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

AU - Disteche, Christine M.

AU - Brannan, Camilynn I.

AU - Larsen, Alf

AU - Adler, David A.

AU - Schorderet, Daniel F.

AU - Gearing, David

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Park, Linda S.

PY - 1992/8

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The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

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