The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Christine M. Disteche, Camilynn I. Brannan, Alf Larsen, David A. Adler, Daniel F. Schorderet, David Gearing, Neal G. Copeland, Nancy A. Jenkins, Linda S. Park

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalNature Genetics
Volume1
Issue number5
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Genetics

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