The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

A. J. Parsian; J. E. Sheren; T. Y. Tao; P. C. Goswami; R. Malyapa; R. Van Rheeden; M. S. Watson; C. R. Hunt

doi:10.1016/s0167-4781(00)00203-7

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

A. J. Parsian, J. E. Sheren, T. Y. Tao, P. C. Goswami, R. Malyapa, R. Van Rheeden, M. S. Watson, C. R. Hunt

Houston Methodist

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	BBA - Biochimica et Biophysica Acta
Volume	1494
Issue number	1-2
DOIs	https://doi.org/10.1016/s0167-4781(00)00203-7
State	Published - Nov 15 2000

Access to Document

10.1016/s0167-4781(00)00203-7

Cite this

@article{ec8941d990a04d6ba77dd2fae5fd550b,

title = "The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.",

abstract = "The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.",

author = "Parsian, \{A. J.\} and Sheren, \{J. E.\} and Tao, \{T. Y.\} and Goswami, \{P. C.\} and R. Malyapa and \{Van Rheeden\}, R. and Watson, \{M. S.\} and Hunt, \{C. R.\}",

note = "Funding Information: This work was supported by NCI Grants CA60757 (C.R.H.) and CA69593 (P.C.G.).",

year = "2000",

month = nov,

day = "15",

doi = "10.1016/s0167-4781(00)00203-7",

language = "English (US)",

volume = "1494",

pages = "201--205",

journal = "BBA - Biochimica et Biophysica Acta",

issn = "0006-3002",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

AU - Parsian, A. J.

AU - Sheren, J. E.

AU - Tao, T. Y.

AU - Goswami, P. C.

AU - Malyapa, R.

AU - Van Rheeden, R.

AU - Watson, M. S.

AU - Hunt, C. R.

N1 - Funding Information: This work was supported by NCI Grants CA60757 (C.R.H.) and CA69593 (P.C.G.).

PY - 2000/11/15

Y1 - 2000/11/15

N2 - The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

AB - The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

UR - https://www.scopus.com/pages/publications/0034668827

UR - https://www.scopus.com/inward/citedby.url?scp=0034668827&partnerID=8YFLogxK

U2 - 10.1016/s0167-4781(00)00203-7

DO - 10.1016/s0167-4781(00)00203-7

M3 - Article

C2 - 11072087

AN - SCOPUS:0034668827

SN - 0006-3002

VL - 1494

SP - 201

EP - 205

JO - BBA - Biochimica et Biophysica Acta

JF - BBA - Biochimica et Biophysica Acta

IS - 1-2

ER -

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this