The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

A. J. Parsian, J. E. Sheren, T. Y. Tao, P. C. Goswami, R. Malyapa, R. Van Rheeden, M. S. Watson, C. R. Hunt

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalBBA - Biochimica et Biophysica Acta
Volume1494
Issue number1-2
DOIs
StatePublished - Nov 15 2000

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