The human gut microbiome and body metabolism: Implications for obesity and diabetes

Sridevi Devaraj, Peera Hemarajata, James Versalovic

Research output: Contribution to journalReview articlepeer-review

242 Scopus citations


Background: Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders. Content: Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways. Conclusion: Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.

Original languageEnglish (US)
Pages (from-to)617-628
Number of pages12
JournalClinical Chemistry
Issue number4
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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