It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.
|Translated title of the contribution||The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine|
|Number of pages||3|
|State||Published - Jan 1 1990|
ASJC Scopus subject areas
- Cancer Research