TY - JOUR
T1 - The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay
AU - Kleman, Marika I.
AU - övervik, Eva
AU - Porsch-hällström, Inger
AU - Blanck, Agneta
AU - Gustafsson, Jan Ake
N1 - Funding Information:
This study was supported by grants from the Swedish Cancer Society, the Bank of Sweden Tercentenary Foundation, the Swedish Council for Forestry and Agricultural Research, the NIEHS, NIH (1RO1CA 57925-01) and the Belvin Foundation.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1993/10
Y1 - 1993/10
N2 - The food-derived heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) are carcinogenic in rodents as well as in non-human primates (IQ). Using a short-term liver carcinogenesis model the compounds were found to be only weak initiators. It is also possible that these amines are involved in other phases of the carcinogenesis process. In an attempt to study the promotive effects of IQ and MeIQx, these heterocyclic amines were repeatedly given by gavage, over a period of 10 days, to Wistar rats previously initiated with diethylnitrosamine (DEN) and subjected to a partial hepatectomy. The rats were killed 1 month after DEN administration and their livers examined for glutathione-S-transferase positive (GST-P) foci. The positive control, 2-acetylaminofluorene, significantly increased the development of GST-P foci in the DEN-treated rats compared to the negative control, saline. However, neither the IQ- nor the MeIQx-treated groups differed from the controls and thus these amines do not promote the growth of DEN-initiated GST-P liver foci in this model.
AB - The food-derived heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) are carcinogenic in rodents as well as in non-human primates (IQ). Using a short-term liver carcinogenesis model the compounds were found to be only weak initiators. It is also possible that these amines are involved in other phases of the carcinogenesis process. In an attempt to study the promotive effects of IQ and MeIQx, these heterocyclic amines were repeatedly given by gavage, over a period of 10 days, to Wistar rats previously initiated with diethylnitrosamine (DEN) and subjected to a partial hepatectomy. The rats were killed 1 month after DEN administration and their livers examined for glutathione-S-transferase positive (GST-P) foci. The positive control, 2-acetylaminofluorene, significantly increased the development of GST-P foci in the DEN-treated rats compared to the negative control, saline. However, neither the IQ- nor the MeIQx-treated groups differed from the controls and thus these amines do not promote the growth of DEN-initiated GST-P liver foci in this model.
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U2 - 10.1093/carcin/14.10.2123
DO - 10.1093/carcin/14.10.2123
M3 - Article
C2 - 8222065
AN - SCOPUS:0027440996
VL - 14
SP - 2123
EP - 2125
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 10
ER -