TY - JOUR
T1 - The hemodynamic and hematologic effects of cigarette smoking versus a nicotine patch
AU - Netscher, Davidt
AU - Wigoda, Paul
AU - Thomby, John
AU - Yip, Bianca
AU - Rappaport, Normanh
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1995/9
Y1 - 1995/9
N2 - Patients who smoke have higher complication rates than nonsmokers in the postoperative period. The authors designed an experimental protocol for habitual smokers (n = 30) to determine the specific hemodynamic and hematologic adverse effects possibly caused by nicotine and whether the method of nicotine delivery and systemic nicotine levels achieved might influence these adverse effects. During the 5-day study, subjects were asked to refrain from smoking, and testing sessions were conducted as follows: on day 1, the subjects smoked two cigarettes immediately before testing; on day 3 (control day), testing was done after not smoking for 48 hours and then the subjects were instructed to wear a transdermal nicotine patch (PROSTEP 22 mg/day) for 24 hours and replace it with another so that, on day 5, testing took place after the subjects had worn the patch for approximately 34 hours. At each testing session, digital artery pulse amplitude and a number of clinical and serum blood level parameters were measured. Relative digital blood flow after smoking (69.2 ± 5.8%) and with the patch (80.4 ± 7.6%) was lower than on the control day (100.0 ± 0.0%). The nicotine patch, unlike smoking, had no effect on vasopressin or fibrinogen concentrations, hematocrit, or white cell of platelet counts; both smoking and the patch resulted in elevated norepinephrine levels.
AB - Patients who smoke have higher complication rates than nonsmokers in the postoperative period. The authors designed an experimental protocol for habitual smokers (n = 30) to determine the specific hemodynamic and hematologic adverse effects possibly caused by nicotine and whether the method of nicotine delivery and systemic nicotine levels achieved might influence these adverse effects. During the 5-day study, subjects were asked to refrain from smoking, and testing sessions were conducted as follows: on day 1, the subjects smoked two cigarettes immediately before testing; on day 3 (control day), testing was done after not smoking for 48 hours and then the subjects were instructed to wear a transdermal nicotine patch (PROSTEP 22 mg/day) for 24 hours and replace it with another so that, on day 5, testing took place after the subjects had worn the patch for approximately 34 hours. At each testing session, digital artery pulse amplitude and a number of clinical and serum blood level parameters were measured. Relative digital blood flow after smoking (69.2 ± 5.8%) and with the patch (80.4 ± 7.6%) was lower than on the control day (100.0 ± 0.0%). The nicotine patch, unlike smoking, had no effect on vasopressin or fibrinogen concentrations, hematocrit, or white cell of platelet counts; both smoking and the patch resulted in elevated norepinephrine levels.
UR - http://www.scopus.com/inward/record.url?scp=0029112675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029112675&partnerID=8YFLogxK
U2 - 10.1097/00006534-199509000-00022
DO - 10.1097/00006534-199509000-00022
M3 - Article
C2 - 7638293
AN - SCOPUS:0029112675
SN - 0032-1052
VL - 96
SP - 681
EP - 688
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
IS - 3
ER -