The helical hydrophobic moment avoids prolines in phospholipid-binding proteins

Henry J. Pownall, Antonio M. Gotto, Roger D. Knapp, John B. Massey

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Proline residues appear to punctuate the distribution of amphiphilic phospholipid-binding regions of apolipoproteins. We have applied a quantitative test to this hypothesis and shown that the magnitude of the helical hydrophobic moment around proline residues is reduced in lipid-binding proteins and peptides.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume139
Issue number1
DOIs
StatePublished - Aug 29 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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