The Hallmarks of Precancer

Mary M. Stangis; Zhengyi Chen; Jimin Min; Sarah E. Glass; Jordan O. Jackson; Megan D. Radyk; Xen Ping Hoi; W. Nathaniel Brennen; Ming Yu; Huy Q. Dinh; Robert J. Coffey; Martha J. Shrubsole; Keith S. Chan; William M. Grady; Srinivasan Yegnasubramanian; Costas A. Lyssiotis; Anirban Maitra; Richard B. Halberg; Neelendu Dey; Ken S. Lau

doi:10.1158/2159-8290.CD-23-1550

The Hallmarks of Precancer

Mary M. Stangis, Zhengyi Chen, Jimin Min, Sarah E. Glass, Jordan O. Jackson, Megan D. Radyk, Xen Ping Hoi, W. Nathaniel Brennen, Ming Yu, Huy Q. Dinh, Robert J. Coffey, Martha J. Shrubsole, Keith S. Chan, William M. Grady, Srinivasan Yegnasubramanian, Costas A. Lyssiotis, Anirban Maitra, Richard B. Halberg, Neelendu Dey, Ken S. Lau

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

Original language	English (US)
Pages (from-to)	683-689
Number of pages	7
Journal	Cancer Discovery
Volume	14
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-23-1550
State	Published - Apr 1 2024

ASJC Scopus subject areas

Oncology

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Stangis, M. M., Chen, Z., Min, J., Glass, S. E., Jackson, J. O., Radyk, M. D., Hoi, X. P., Brennen, W. N., Yu, M., Dinh, H. Q., Coffey, R. J., Shrubsole, M. J., Chan, K. S., Grady, W. M., Yegnasubramanian, S., Lyssiotis, C. A., Maitra, A., Halberg, R. B., Dey, N., & Lau, K. S. (2024). The Hallmarks of Precancer. Cancer Discovery, 14(4), 683-689. https://doi.org/10.1158/2159-8290.CD-23-1550

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abstract = "Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.",

author = "Stangis, \{Mary M.\} and Zhengyi Chen and Jimin Min and Glass, \{Sarah E.\} and Jackson, \{Jordan O.\} and Radyk, \{Megan D.\} and Hoi, \{Xen Ping\} and Brennen, \{W. Nathaniel\} and Ming Yu and Dinh, \{Huy Q.\} and Coffey, \{Robert J.\} and Shrubsole, \{Martha J.\} and Chan, \{Keith S.\} and Grady, \{William M.\} and Srinivasan Yegnasubramanian and Lyssiotis, \{Costas A.\} and Anirban Maitra and Halberg, \{Richard B.\} and Neelendu Dey and Lau, \{Ken S.\}",

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doi = "10.1158/2159-8290.CD-23-1550",

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AU - Stangis, Mary M.

AU - Chen, Zhengyi

AU - Min, Jimin

AU - Glass, Sarah E.

AU - Jackson, Jordan O.

AU - Radyk, Megan D.

AU - Hoi, Xen Ping

AU - Brennen, W. Nathaniel

AU - Yu, Ming

AU - Dinh, Huy Q.

AU - Coffey, Robert J.

AU - Shrubsole, Martha J.

AU - Chan, Keith S.

AU - Grady, William M.

AU - Yegnasubramanian, Srinivasan

AU - Lyssiotis, Costas A.

AU - Maitra, Anirban

AU - Halberg, Richard B.

AU - Dey, Neelendu

AU - Lau, Ken S.

PY - 2024/4/1

Y1 - 2024/4/1

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AB - Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

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The Hallmarks of Precancer

Abstract

ASJC Scopus subject areas

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