Abstract
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2185-2195 |
| Number of pages | 11 |
| Journal | Science |
| Volume | 287 |
| Issue number | 5461 |
| DOIs | |
| State | Published - Mar 24 2000 |
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The genome sequence of Drosophila melanogaster. / Adams, M. D.; Celniker, S. E.; Holt, R. A.; Evans, C. A.; Gocayne, J. D.; Amanatides, P. G.; Scherer, S. E.; Li, P. W.; Hoskins, R. A.; Galle, R. F.; George, R. A.; Lewis, S. E.; Richards, S.; Ashburner, M.; Henderson, S. N.; Sutton, G. G.; Wortman, J. R.; Yandell, M. D.; Zhang, Q.; Chen, L. X.; Brandon, R. C.; Rogers, Y. H C; Blazej, R. G.; Champe, M.; Pfeiffer, B. D.; Wan, K. H.; Doyle, C.; Baxter, E. G.; Helt, G.; Nelson, C. R.; Gabor Miklos, G. L.; Abril, J. F.; Agbayani, A.; An, H. J.; Andrews-Pfannkoch, C.; Baldwin, D.; Ballew, R. M.; Basu, A.; Baxendale, J.; Bayraktaroglu, L.; Beasley, E. M.; Beeson, K. Y.; Benos, P. V.; Berman, B. P.; Bhandari, D.; Bolshakov, S.; Borkova, D.; Botchan, M. R.; Bouck, J.; Brokstein, P.; Brottier, P.; Burtis, K. C.; Busam, D. A.; Butler, H.; Cadieu, E.; Center, A.; Chandra, I.; Michael Cherry, J.; Cawley, S.; Dahlke, C.; Davenport, L. B.; Davies, P.; de Pablos, B.; Delcher, A.; Deng, Z.; Deslattes Mays, A.; Dew, I.; Dietz, S. M.; Dodson, K.; Doup, L. E.; Downes, M.; Dugan-Rocha, S.; Dunkov, B. C.; Dunn, P.; Durbin, K. J.; Evangelista, C. C.; Ferraz, C.; Ferriera, S.; Fleischmann, W.; Fosler, C.; Gabrielian, A. E.; Garg, N. S.; Gelbart, W. M.; Glasser, K.; Glodek, A.; Gong, F.; Harley Gorrell, J.; Gu, Z.; Guan, P.; Harris, M.; Harris, N. L.; Harvey, D.; Heiman, T. J.; Hernandez, J. R.; Houck, J.; Hostin, D.; Houston, K. A.; Howland, T. J.; Wei, M. H.; Ibegwam, C.; Jalali, M.; Kalush, F.; Karpen, G. H.; Ke, Z.; Kennison, J. A.; Ketchum, K. A.; Kimmel, B. E.; Kodira, C. D.; Kraft, C.; Kravitz, S.; Kulp, D.; Lai, Z.; Lasko, P.; Lei, Y.; Levitsky, A. A.; Li, J.; Li, Z.; Liang, Y.; Lin, X.; Liu, X.; Mattei, B.; McIntosh, T. C.; McLeod, M. P.; McPherson, D.; Merkulov, G.; Milshina, N. V.; Mobarry, C.; Morris, J.; Moshrefi, A.; Mount, S. M.; Moy, M.; Murphy, B.; Murphy, L.; Muzny, D. M.; Nelson, D. L.; Nelson, D. R.; Nelson, K. A.; Nixon, K.; Nusskern, D. R.; Pacleb, J. M.; Palazzolo, M.; Pittman, G. S.; Pan, S.; Pollard, J.; Puri, V.; Reese, M. G.; Reinert, K.; Remington, K.; Saunders, R. D C; Scheeler, F.; Shen, H.; Christopher Shue, B.; Siden-Kiamos, I.; Simpson, M.; Skupski, M. P.; Smith, T.; Spier, E.; Spradling, A. C.; Stapleton, M.; Strong, R.; Sun, E.; Svirskas, R.; Tector, C.; Turner, R.; Venter, E.; Wang, A. H.; Wang, X.; Wang, Z. Y.; Wassarman, D. A.; Weinstock, G. M.; Weissenbach, J.; Williams, S. M.; Woodage, T.; Worley, K. C.; Wu, D.; Yang, S.; Alison Yao, Q.; Ye, J.; Yeh, R. F.; Zaveri, J. S.; Zhan, M.; Zhang, G.; Zhao, Q.; Zheng, L.; Zheng, X. H.; Zhong, F. N.; Zhong, W.; Zhou, X.; Zhu, S.; Zhu, X.; Smith, H. O.; Gibbs, R. A.; Myers, E. W.; Rubin, G. M.; Craig Venter, J.
In: Science, Vol. 287, No. 5461, 24.03.2000, p. 2185-2195.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - The genome sequence of Drosophila melanogaster
AU - Adams, M. D.
AU - Celniker, S. E.
AU - Holt, R. A.
AU - Evans, C. A.
AU - Gocayne, J. D.
AU - Amanatides, P. G.
AU - Scherer, S. E.
AU - Li, P. W.
AU - Hoskins, R. A.
AU - Galle, R. F.
AU - George, R. A.
AU - Lewis, S. E.
AU - Richards, S.
AU - Ashburner, M.
AU - Henderson, S. N.
AU - Sutton, G. G.
AU - Wortman, J. R.
AU - Yandell, M. D.
AU - Zhang, Q.
AU - Chen, L. X.
AU - Brandon, R. C.
AU - Rogers, Y. H C
AU - Blazej, R. G.
AU - Champe, M.
AU - Pfeiffer, B. D.
AU - Wan, K. H.
AU - Doyle, C.
AU - Baxter, E. G.
AU - Helt, G.
AU - Nelson, C. R.
AU - Gabor Miklos, G. L.
AU - Abril, J. F.
AU - Agbayani, A.
AU - An, H. J.
AU - Andrews-Pfannkoch, C.
AU - Baldwin, D.
AU - Ballew, R. M.
AU - Basu, A.
AU - Baxendale, J.
AU - Bayraktaroglu, L.
AU - Beasley, E. M.
AU - Beeson, K. Y.
AU - Benos, P. V.
AU - Berman, B. P.
AU - Bhandari, D.
AU - Bolshakov, S.
AU - Borkova, D.
AU - Botchan, M. R.
AU - Bouck, J.
AU - Brokstein, P.
AU - Brottier, P.
AU - Burtis, K. C.
AU - Busam, D. A.
AU - Butler, H.
AU - Cadieu, E.
AU - Center, A.
AU - Chandra, I.
AU - Michael Cherry, J.
AU - Cawley, S.
AU - Dahlke, C.
AU - Davenport, L. B.
AU - Davies, P.
AU - de Pablos, B.
AU - Delcher, A.
AU - Deng, Z.
AU - Deslattes Mays, A.
AU - Dew, I.
AU - Dietz, S. M.
AU - Dodson, K.
AU - Doup, L. E.
AU - Downes, M.
AU - Dugan-Rocha, S.
AU - Dunkov, B. C.
AU - Dunn, P.
AU - Durbin, K. J.
AU - Evangelista, C. C.
AU - Ferraz, C.
AU - Ferriera, S.
AU - Fleischmann, W.
AU - Fosler, C.
AU - Gabrielian, A. E.
AU - Garg, N. S.
AU - Gelbart, W. M.
AU - Glasser, K.
AU - Glodek, A.
AU - Gong, F.
AU - Harley Gorrell, J.
AU - Gu, Z.
AU - Guan, P.
AU - Harris, M.
AU - Harris, N. L.
AU - Harvey, D.
AU - Heiman, T. J.
AU - Hernandez, J. R.
AU - Houck, J.
AU - Hostin, D.
AU - Houston, K. A.
AU - Howland, T. J.
AU - Wei, M. H.
AU - Ibegwam, C.
AU - Jalali, M.
AU - Kalush, F.
AU - Karpen, G. H.
AU - Ke, Z.
AU - Kennison, J. A.
AU - Ketchum, K. A.
AU - Kimmel, B. E.
AU - Kodira, C. D.
AU - Kraft, C.
AU - Kravitz, S.
AU - Kulp, D.
AU - Lai, Z.
AU - Lasko, P.
AU - Lei, Y.
AU - Levitsky, A. A.
AU - Li, J.
AU - Li, Z.
AU - Liang, Y.
AU - Lin, X.
AU - Liu, X.
AU - Mattei, B.
AU - McIntosh, T. C.
AU - McLeod, M. P.
AU - McPherson, D.
AU - Merkulov, G.
AU - Milshina, N. V.
AU - Mobarry, C.
AU - Morris, J.
AU - Moshrefi, A.
AU - Mount, S. M.
AU - Moy, M.
AU - Murphy, B.
AU - Murphy, L.
AU - Muzny, D. M.
AU - Nelson, D. L.
AU - Nelson, D. R.
AU - Nelson, K. A.
AU - Nixon, K.
AU - Nusskern, D. R.
AU - Pacleb, J. M.
AU - Palazzolo, M.
AU - Pittman, G. S.
AU - Pan, S.
AU - Pollard, J.
AU - Puri, V.
AU - Reese, M. G.
AU - Reinert, K.
AU - Remington, K.
AU - Saunders, R. D C
AU - Scheeler, F.
AU - Shen, H.
AU - Christopher Shue, B.
AU - Siden-Kiamos, I.
AU - Simpson, M.
AU - Skupski, M. P.
AU - Smith, T.
AU - Spier, E.
AU - Spradling, A. C.
AU - Stapleton, M.
AU - Strong, R.
AU - Sun, E.
AU - Svirskas, R.
AU - Tector, C.
AU - Turner, R.
AU - Venter, E.
AU - Wang, A. H.
AU - Wang, X.
AU - Wang, Z. Y.
AU - Wassarman, D. A.
AU - Weinstock, G. M.
AU - Weissenbach, J.
AU - Williams, S. M.
AU - Woodage, T.
AU - Worley, K. C.
AU - Wu, D.
AU - Yang, S.
AU - Alison Yao, Q.
AU - Ye, J.
AU - Yeh, R. F.
AU - Zaveri, J. S.
AU - Zhan, M.
AU - Zhang, G.
AU - Zhao, Q.
AU - Zheng, L.
AU - Zheng, X. H.
AU - Zhong, F. N.
AU - Zhong, W.
AU - Zhou, X.
AU - Zhu, S.
AU - Zhu, X.
AU - Smith, H. O.
AU - Gibbs, R. A.
AU - Myers, E. W.
AU - Rubin, G. M.
AU - Craig Venter, J.
N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000/3/24
Y1 - 2000/3/24
N2 - The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
AB - The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
UR - http://www.scopus.com/inward/record.url?scp=0034708480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034708480&partnerID=8YFLogxK
U2 - 10.1126/science.287.5461.2185
DO - 10.1126/science.287.5461.2185
M3 - Review article
C2 - 10731132
AN - SCOPUS:0034708480
VL - 287
SP - 2185
EP - 2195
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 5461
ER -