The genome sequence of Drosophila melanogaster

M. D. Adams; S. E. Celniker; R. A. Holt; C. A. Evans; J. D. Gocayne; P. G. Amanatides; S. E. Scherer; P. W. Li; R. A. Hoskins; R. F. Galle; R. A. George; S. E. Lewis; S. Richards; M. Ashburner; S. N. Henderson; G. G. Sutton; J. R. Wortman; M. D. Yandell; Q. Zhang; L. X. Chen; R. C. Brandon; Y. H C Rogers; R. G. Blazej; M. Champe; B. D. Pfeiffer; K. H. Wan; C. Doyle; E. G. Baxter; G. Helt; C. R. Nelson; G. L. Gabor Miklos; J. F. Abril; A. Agbayani; H. J. An; C. Andrews-Pfannkoch; D. Baldwin; R. M. Ballew; A. Basu; J. Baxendale; L. Bayraktaroglu; E. M. Beasley; K. Y. Beeson; P. V. Benos; B. P. Berman; D. Bhandari; S. Bolshakov; D. Borkova; M. R. Botchan; J. Bouck; P. Brokstein; P. Brottier; K. C. Burtis; D. A. Busam; H. Butler; E. Cadieu; A. Center; I. Chandra; J. Michael Cherry; S. Cawley; C. Dahlke; L. B. Davenport; P. Davies; B. de Pablos; A. Delcher; Z. Deng; A. Deslattes Mays; I. Dew; S. M. Dietz; K. Dodson; L. E. Doup; M. Downes; S. Dugan-Rocha; B. C. Dunkov; P. Dunn; K. J. Durbin; C. C. Evangelista; C. Ferraz; S. Ferriera; W. Fleischmann; C. Fosler; A. E. Gabrielian; N. S. Garg; W. M. Gelbart; K. Glasser; A. Glodek; F. Gong; J. Harley Gorrell; Z. Gu; P. Guan; M. Harris; N. L. Harris; D. Harvey; T. J. Heiman; J. R. Hernandez; J. Houck; D. Hostin; K. A. Houston; T. J. Howland; M. H. Wei; C. Ibegwam; M. Jalali; F. Kalush; G. H. Karpen; Z. Ke; J. A. Kennison; K. A. Ketchum; B. E. Kimmel; C. D. Kodira; C. Kraft; S. Kravitz; D. Kulp; Z. Lai; P. Lasko; Y. Lei; A. A. Levitsky; J. Li; Z. Li; Y. Liang; X. Lin; X. Liu; B. Mattei; T. C. McIntosh; M. P. McLeod; D. McPherson; G. Merkulov; N. V. Milshina; C. Mobarry; J. Morris; A. Moshrefi; S. M. Mount; M. Moy; B. Murphy; L. Murphy; D. M. Muzny; D. L. Nelson; D. R. Nelson; K. A. Nelson; K. Nixon; D. R. Nusskern; J. M. Pacleb; M. Palazzolo; G. S. Pittman; S. Pan; J. Pollard; V. Puri; M. G. Reese; K. Reinert; K. Remington; R. D C Saunders; F. Scheeler; H. Shen; B. Christopher Shue; I. Siden-Kiamos; M. Simpson; M. P. Skupski; T. Smith; E. Spier; A. C. Spradling; M. Stapleton; R. Strong; E. Sun; R. Svirskas; C. Tector; R. Turner; E. Venter; A. H. Wang; X. Wang; Z. Y. Wang; D. A. Wassarman; G. M. Weinstock; J. Weissenbach; S. M. Williams; T. Woodage; K. C. Worley; D. Wu; S. Yang; Q. Alison Yao; J. Ye; R. F. Yeh; J. S. Zaveri; M. Zhan; G. Zhang; Q. Zhao; L. Zheng; X. H. Zheng; F. N. Zhong; W. Zhong; X. Zhou; S. Zhu; X. Zhu; H. O. Smith; R. A. Gibbs; E. W. Myers; G. M. Rubin; J. Craig Venter

doi:10.1126/science.287.5461.2185

The genome sequence of Drosophila melanogaster

M. D. Adams, S. E. Celniker, R. A. Holt, C. A. Evans, J. D. Gocayne, P. G. Amanatides, S. E. Scherer, P. W. Li, R. A. Hoskins, R. F. Galle, R. A. George, S. E. Lewis, S. Richards, M. Ashburner, S. N. Henderson, G. G. Sutton, J. R. Wortman, M. D. Yandell, Q. Zhang, L. X. ChenR. C. Brandon, Y. H C Rogers, R. G. Blazej, M. Champe, B. D. Pfeiffer, K. H. Wan, C. Doyle, E. G. Baxter, G. Helt, C. R. Nelson, G. L. Gabor Miklos, J. F. Abril, A. Agbayani, H. J. An, C. Andrews-Pfannkoch, D. Baldwin, R. M. Ballew, A. Basu, J. Baxendale, L. Bayraktaroglu, E. M. Beasley, K. Y. Beeson, P. V. Benos, B. P. Berman, D. Bhandari, S. Bolshakov, D. Borkova, M. R. Botchan, J. Bouck, P. Brokstein, P. Brottier, K. C. Burtis, D. A. Busam, H. Butler, E. Cadieu, A. Center, I. Chandra, J. Michael Cherry, S. Cawley, C. Dahlke, L. B. Davenport, P. Davies, B. de Pablos, A. Delcher, Z. Deng, A. Deslattes Mays, I. Dew, S. M. Dietz, K. Dodson, L. E. Doup, M. Downes, S. Dugan-Rocha, B. C. Dunkov, P. Dunn, K. J. Durbin, C. C. Evangelista, C. Ferraz, S. Ferriera, W. Fleischmann, C. Fosler, A. E. Gabrielian, N. S. Garg, W. M. Gelbart, K. Glasser, A. Glodek, F. Gong, J. Harley Gorrell, Z. Gu, P. Guan, M. Harris, N. L. Harris, D. Harvey, T. J. Heiman, J. R. Hernandez, J. Houck, D. Hostin, K. A. Houston, T. J. Howland, M. H. Wei, C. Ibegwam, M. Jalali, F. Kalush, G. H. Karpen, Z. Ke, J. A. Kennison, K. A. Ketchum, B. E. Kimmel, C. D. Kodira, C. Kraft, S. Kravitz, D. Kulp, Z. Lai, P. Lasko, Y. Lei, A. A. Levitsky, J. Li, Z. Li, Y. Liang, X. Lin, X. Liu, B. Mattei, T. C. McIntosh, M. P. McLeod, D. McPherson, G. Merkulov, N. V. Milshina, C. Mobarry, J. Morris, A. Moshrefi, S. M. Mount, M. Moy, B. Murphy, L. Murphy, D. M. Muzny, D. L. Nelson, D. R. Nelson, K. A. Nelson, K. Nixon, D. R. Nusskern, J. M. Pacleb, M. Palazzolo, G. S. Pittman, S. Pan, J. Pollard, V. Puri, M. G. Reese, K. Reinert, K. Remington, R. D C Saunders, F. Scheeler, H. Shen, B. Christopher Shue, I. Siden-Kiamos, M. Simpson, M. P. Skupski, T. Smith, E. Spier, A. C. Spradling, M. Stapleton, R. Strong, E. Sun, R. Svirskas, C. Tector, R. Turner, E. Venter, A. H. Wang, X. Wang, Z. Y. Wang, D. A. Wassarman, G. M. Weinstock, J. Weissenbach, S. M. Williams, T. Woodage, K. C. Worley, D. Wu, S. Yang, Q. Alison Yao, J. Ye, R. F. Yeh, J. S. Zaveri, M. Zhan, G. Zhang, Q. Zhao, L. Zheng, X. H. Zheng, F. N. Zhong, W. Zhong, X. Zhou, S. Zhu, X. Zhu, H. O. Smith, R. A. Gibbs, E. W. Myers, G. M. Rubin, J. Craig Venter

Research output: Contribution to journal › Review article › peer-review

4817 Scopus citations

Abstract

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

Original language	English (US)
Pages (from-to)	2185-2195
Number of pages	11
Journal	Science
Volume	287
Issue number	5461
DOIs	https://doi.org/10.1126/science.287.5461.2185
State	Published - Mar 24 2000

ASJC Scopus subject areas

General

Access to Document

10.1126/science.287.5461.2185

Cite this

Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., George, R. A., Lewis, S. E., Richards, S., Ashburner, M., Henderson, S. N., Sutton, G. G., Wortman, J. R., Yandell, M. D., Zhang, Q., ... Craig Venter, J. (2000). The genome sequence of Drosophila melanogaster. Science, 287(5461), 2185-2195. https://doi.org/10.1126/science.287.5461.2185

Adams, MD, Celniker, SE, Holt, RA, Evans, CA, Gocayne, JD, Amanatides, PG, Scherer, SE, Li, PW, Hoskins, RA, Galle, RF, George, RA, Lewis, SE, Richards, S, Ashburner, M, Henderson, SN, Sutton, GG, Wortman, JR, Yandell, MD, Zhang, Q, Chen, LX, Brandon, RC, Rogers, YHC, Blazej, RG, Champe, M, Pfeiffer, BD, Wan, KH, Doyle, C, Baxter, EG, Helt, G, Nelson, CR, Gabor Miklos, GL, Abril, JF, Agbayani, A, An, HJ, Andrews-Pfannkoch, C, Baldwin, D, Ballew, RM, Basu, A, Baxendale, J, Bayraktaroglu, L, Beasley, EM, Beeson, KY, Benos, PV, Berman, BP, Bhandari, D, Bolshakov, S, Borkova, D, Botchan, MR, Bouck, J, Brokstein, P, Brottier, P, Burtis, KC, Busam, DA, Butler, H, Cadieu, E, Center, A, Chandra, I, Michael Cherry, J, Cawley, S, Dahlke, C, Davenport, LB, Davies, P, de Pablos, B, Delcher, A, Deng, Z, Deslattes Mays, A, Dew, I, Dietz, SM, Dodson, K, Doup, LE, Downes, M, Dugan-Rocha, S, Dunkov, BC, Dunn, P, Durbin, KJ, Evangelista, CC, Ferraz, C, Ferriera, S, Fleischmann, W, Fosler, C, Gabrielian, AE, Garg, NS, Gelbart, WM, Glasser, K, Glodek, A, Gong, F, Harley Gorrell, J, Gu, Z, Guan, P, Harris, M, Harris, NL, Harvey, D, Heiman, TJ, Hernandez, JR, Houck, J, Hostin, D, Houston, KA, Howland, TJ, Wei, MH, Ibegwam, C, Jalali, M, Kalush, F, Karpen, GH, Ke, Z, Kennison, JA, Ketchum, KA, Kimmel, BE, Kodira, CD, Kraft, C, Kravitz, S, Kulp, D, Lai, Z, Lasko, P, Lei, Y, Levitsky, AA, Li, J, Li, Z, Liang, Y, Lin, X, Liu, X, Mattei, B, McIntosh, TC, McLeod, MP, McPherson, D, Merkulov, G, Milshina, NV, Mobarry, C, Morris, J, Moshrefi, A, Mount, SM, Moy, M, Murphy, B, Murphy, L, Muzny, DM, Nelson, DL, Nelson, DR, Nelson, KA, Nixon, K, Nusskern, DR, Pacleb, JM, Palazzolo, M, Pittman, GS, Pan, S, Pollard, J, Puri, V, Reese, MG, Reinert, K, Remington, K, Saunders, RDC, Scheeler, F, Shen, H, Christopher Shue, B, Siden-Kiamos, I, Simpson, M, Skupski, MP, Smith, T, Spier, E, Spradling, AC, Stapleton, M, Strong, R, Sun, E, Svirskas, R, Tector, C, Turner, R, Venter, E, Wang, AH, Wang, X, Wang, ZY, Wassarman, DA, Weinstock, GM, Weissenbach, J, Williams, SM, Woodage, T, Worley, KC, Wu, D, Yang, S, Alison Yao, Q, Ye, J, Yeh, RF, Zaveri, JS, Zhan, M, Zhang, G, Zhao, Q, Zheng, L, Zheng, XH, Zhong, FN, Zhong, W, Zhou, X, Zhu, S, Zhu, X, Smith, HO, Gibbs, RA, Myers, EW, Rubin, GM & Craig Venter, J 2000, 'The genome sequence of Drosophila melanogaster', Science, vol. 287, no. 5461, pp. 2185-2195. https://doi.org/10.1126/science.287.5461.2185

@article{37bfb28a8a62441f9f34b4cf4bb5f1ba,

title = "The genome sequence of Drosophila melanogaster",

abstract = "The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.",

author = "Adams, {M. D.} and Celniker, {S. E.} and Holt, {R. A.} and Evans, {C. A.} and Gocayne, {J. D.} and Amanatides, {P. G.} and Scherer, {S. E.} and Li, {P. W.} and Hoskins, {R. A.} and Galle, {R. F.} and George, {R. A.} and Lewis, {S. E.} and S. Richards and M. Ashburner and Henderson, {S. N.} and Sutton, {G. G.} and Wortman, {J. R.} and Yandell, {M. D.} and Q. Zhang and Chen, {L. X.} and Brandon, {R. C.} and Rogers, {Y. H C} and Blazej, {R. G.} and M. Champe and Pfeiffer, {B. D.} and Wan, {K. H.} and C. Doyle and Baxter, {E. G.} and G. Helt and Nelson, {C. R.} and {Gabor Miklos}, {G. L.} and Abril, {J. F.} and A. Agbayani and An, {H. J.} and C. Andrews-Pfannkoch and D. Baldwin and Ballew, {R. M.} and A. Basu and J. Baxendale and L. Bayraktaroglu and Beasley, {E. M.} and Beeson, {K. Y.} and Benos, {P. V.} and Berman, {B. P.} and D. Bhandari and S. Bolshakov and D. Borkova and Botchan, {M. R.} and J. Bouck and P. Brokstein and P. Brottier and Burtis, {K. C.} and Busam, {D. A.} and H. Butler and E. Cadieu and A. Center and I. Chandra and {Michael Cherry}, J. and S. Cawley and C. Dahlke and Davenport, {L. B.} and P. Davies and {de Pablos}, B. and A. Delcher and Z. Deng and {Deslattes Mays}, A. and I. Dew and Dietz, {S. M.} and K. Dodson and Doup, {L. E.} and M. Downes and S. Dugan-Rocha and Dunkov, {B. C.} and P. Dunn and Durbin, {K. J.} and Evangelista, {C. C.} and C. Ferraz and S. Ferriera and W. Fleischmann and C. Fosler and Gabrielian, {A. E.} and Garg, {N. S.} and Gelbart, {W. M.} and K. Glasser and A. Glodek and F. Gong and {Harley Gorrell}, J. and Z. Gu and P. Guan and M. Harris and Harris, {N. L.} and D. Harvey and Heiman, {T. J.} and Hernandez, {J. R.} and J. Houck and D. Hostin and Houston, {K. A.} and Howland, {T. J.} and Wei, {M. H.} and C. Ibegwam and M. Jalali and F. Kalush and Karpen, {G. H.} and Z. Ke and Kennison, {J. A.} and Ketchum, {K. A.} and Kimmel, {B. E.} and Kodira, {C. D.} and C. Kraft and S. Kravitz and D. Kulp and Z. Lai and P. Lasko and Y. Lei and Levitsky, {A. A.} and J. Li and Z. Li and Y. Liang and X. Lin and X. Liu and B. Mattei and McIntosh, {T. C.} and McLeod, {M. P.} and D. McPherson and G. Merkulov and Milshina, {N. V.} and C. Mobarry and J. Morris and A. Moshrefi and Mount, {S. M.} and M. Moy and B. Murphy and L. Murphy and Muzny, {D. M.} and Nelson, {D. L.} and Nelson, {D. R.} and Nelson, {K. A.} and K. Nixon and Nusskern, {D. R.} and Pacleb, {J. M.} and M. Palazzolo and Pittman, {G. S.} and S. Pan and J. Pollard and V. Puri and Reese, {M. G.} and K. Reinert and K. Remington and Saunders, {R. D C} and F. Scheeler and H. Shen and {Christopher Shue}, B. and I. Siden-Kiamos and M. Simpson and Skupski, {M. P.} and T. Smith and E. Spier and Spradling, {A. C.} and M. Stapleton and R. Strong and E. Sun and R. Svirskas and C. Tector and R. Turner and E. Venter and Wang, {A. H.} and X. Wang and Wang, {Z. Y.} and Wassarman, {D. A.} and Weinstock, {G. M.} and J. Weissenbach and Williams, {S. M.} and T. Woodage and Worley, {K. C.} and D. Wu and S. Yang and {Alison Yao}, Q. and J. Ye and Yeh, {R. F.} and Zaveri, {J. S.} and M. Zhan and G. Zhang and Q. Zhao and L. Zheng and Zheng, {X. H.} and Zhong, {F. N.} and W. Zhong and X. Zhou and S. Zhu and X. Zhu and Smith, {H. O.} and Gibbs, {R. A.} and Myers, {E. W.} and Rubin, {G. M.} and {Craig Venter}, J.",

year = "2000",

month = mar,

day = "24",

doi = "10.1126/science.287.5461.2185",

language = "English (US)",

volume = "287",

pages = "2185--2195",

journal = "Science (New York, N.Y.)",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5461",

}

TY - JOUR

T1 - The genome sequence of Drosophila melanogaster

AU - Adams, M. D.

AU - Celniker, S. E.

AU - Holt, R. A.

AU - Evans, C. A.

AU - Gocayne, J. D.

AU - Amanatides, P. G.

AU - Scherer, S. E.

AU - Li, P. W.

AU - Hoskins, R. A.

AU - Galle, R. F.

AU - George, R. A.

AU - Lewis, S. E.

AU - Richards, S.

AU - Ashburner, M.

AU - Henderson, S. N.

AU - Sutton, G. G.

AU - Wortman, J. R.

AU - Yandell, M. D.

AU - Zhang, Q.

AU - Chen, L. X.

AU - Brandon, R. C.

AU - Rogers, Y. H C

AU - Blazej, R. G.

AU - Champe, M.

AU - Pfeiffer, B. D.

AU - Wan, K. H.

AU - Doyle, C.

AU - Baxter, E. G.

AU - Helt, G.

AU - Nelson, C. R.

AU - Gabor Miklos, G. L.

AU - Abril, J. F.

AU - Agbayani, A.

AU - An, H. J.

AU - Andrews-Pfannkoch, C.

AU - Baldwin, D.

AU - Ballew, R. M.

AU - Basu, A.

AU - Baxendale, J.

AU - Bayraktaroglu, L.

AU - Beasley, E. M.

AU - Beeson, K. Y.

AU - Benos, P. V.

AU - Berman, B. P.

AU - Bhandari, D.

AU - Bolshakov, S.

AU - Borkova, D.

AU - Botchan, M. R.

AU - Bouck, J.

AU - Brokstein, P.

AU - Brottier, P.

AU - Burtis, K. C.

AU - Busam, D. A.

AU - Butler, H.

AU - Cadieu, E.

AU - Center, A.

AU - Chandra, I.

AU - Michael Cherry, J.

AU - Cawley, S.

AU - Dahlke, C.

AU - Davenport, L. B.

AU - Davies, P.

AU - de Pablos, B.

AU - Delcher, A.

AU - Deng, Z.

AU - Deslattes Mays, A.

AU - Dew, I.

AU - Dietz, S. M.

AU - Dodson, K.

AU - Doup, L. E.

AU - Downes, M.

AU - Dugan-Rocha, S.

AU - Dunkov, B. C.

AU - Dunn, P.

AU - Durbin, K. J.

AU - Evangelista, C. C.

AU - Ferraz, C.

AU - Ferriera, S.

AU - Fleischmann, W.

AU - Fosler, C.

AU - Gabrielian, A. E.

AU - Garg, N. S.

AU - Gelbart, W. M.

AU - Glasser, K.

AU - Glodek, A.

AU - Gong, F.

AU - Harley Gorrell, J.

AU - Gu, Z.

AU - Guan, P.

AU - Harris, M.

AU - Harris, N. L.

AU - Harvey, D.

AU - Heiman, T. J.

AU - Hernandez, J. R.

AU - Houck, J.

AU - Hostin, D.

AU - Houston, K. A.

AU - Howland, T. J.

AU - Wei, M. H.

AU - Ibegwam, C.

AU - Jalali, M.

AU - Kalush, F.

AU - Karpen, G. H.

AU - Ke, Z.

AU - Kennison, J. A.

AU - Ketchum, K. A.

AU - Kimmel, B. E.

AU - Kodira, C. D.

AU - Kraft, C.

AU - Kravitz, S.

AU - Kulp, D.

AU - Lai, Z.

AU - Lasko, P.

AU - Lei, Y.

AU - Levitsky, A. A.

AU - Li, J.

AU - Li, Z.

AU - Liang, Y.

AU - Lin, X.

AU - Liu, X.

AU - Mattei, B.

AU - McIntosh, T. C.

AU - McLeod, M. P.

AU - McPherson, D.

AU - Merkulov, G.

AU - Milshina, N. V.

AU - Mobarry, C.

AU - Morris, J.

AU - Moshrefi, A.

AU - Mount, S. M.

AU - Moy, M.

AU - Murphy, B.

AU - Murphy, L.

AU - Muzny, D. M.

AU - Nelson, D. L.

AU - Nelson, D. R.

AU - Nelson, K. A.

AU - Nixon, K.

AU - Nusskern, D. R.

AU - Pacleb, J. M.

AU - Palazzolo, M.

AU - Pittman, G. S.

AU - Pan, S.

AU - Pollard, J.

AU - Puri, V.

AU - Reese, M. G.

AU - Reinert, K.

AU - Remington, K.

AU - Saunders, R. D C

AU - Scheeler, F.

AU - Shen, H.

AU - Christopher Shue, B.

AU - Siden-Kiamos, I.

AU - Simpson, M.

AU - Skupski, M. P.

AU - Smith, T.

AU - Spier, E.

AU - Spradling, A. C.

AU - Stapleton, M.

AU - Strong, R.

AU - Sun, E.

AU - Svirskas, R.

AU - Tector, C.

AU - Turner, R.

AU - Venter, E.

AU - Wang, A. H.

AU - Wang, X.

AU - Wang, Z. Y.

AU - Wassarman, D. A.

AU - Weinstock, G. M.

AU - Weissenbach, J.

AU - Williams, S. M.

AU - Woodage, T.

AU - Worley, K. C.

AU - Wu, D.

AU - Yang, S.

AU - Alison Yao, Q.

AU - Ye, J.

AU - Yeh, R. F.

AU - Zaveri, J. S.

AU - Zhan, M.

AU - Zhang, G.

AU - Zhao, Q.

AU - Zheng, L.

AU - Zheng, X. H.

AU - Zhong, F. N.

AU - Zhong, W.

AU - Zhou, X.

AU - Zhu, S.

AU - Zhu, X.

AU - Smith, H. O.

AU - Gibbs, R. A.

AU - Myers, E. W.

AU - Rubin, G. M.

AU - Craig Venter, J.

PY - 2000/3/24

Y1 - 2000/3/24

N2 - The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

AB - The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ~120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps, however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ~13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

UR - http://www.scopus.com/inward/record.url?scp=0034708480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034708480&partnerID=8YFLogxK

U2 - 10.1126/science.287.5461.2185

DO - 10.1126/science.287.5461.2185

M3 - Review article

C2 - 10731132

AN - SCOPUS:0034708480

VL - 287

SP - 2185

EP - 2195

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

SN - 0036-8075

IS - 5461

ER -

The genome sequence of Drosophila melanogaster

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