The gene for the retinal pigment epithelium-specific protein rpe65 is localized to human 1p31 and mouse 3

Christian P. Hamel, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, T. Michael Redmond

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The human and murine chromosomal localization for the gene for the retinal pigment epithelium-specific protein RPE65 was determined. Using interspecific backcross analysis, we mapped Rpe65 to the distal end of mouse chromosome 3. In the human, using a human-hamster hybrid panel, RPE65 was mapped to chromosome 1. By the use of fluorescence in situ hybridization, this localization was refined to 1p31. The mouse and human loci for this potential candidate gene for hereditary retinal disease do not match those of any known disease in mouse or man.

Original languageEnglish (US)
Pages (from-to)509-512
Number of pages4
JournalGenomics
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Genetics

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