The G209A mutation in the α-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations

William W. Wang, Mehrdad Khajavi, Bhavna J. Patel, Jennifer Beach, Joseph Jankovic, Tetsuo Ashizawa

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective: To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the α-synuclein gene is responsible for familial Parkinson disease (PD) in the US population. Design: Polymerase chain reaction-based DNA analysis of consecutive patients with PD and family history of PD. Setting: A university-affiliated movement disorder clinic and a Veterans Affairs clinical research laboratory. Patients: Forty-four patients with PD and family history of PD and 29 patients with sporadic PD, all with no known Greek and/or Italian background. Results: None of the DNA samples showed the G209A mutation. Conclusion: The G209A mutation is rare in US patients with familial PD.

Original languageEnglish (US)
Pages (from-to)1521-1523
Number of pages3
JournalArchives of neurology
Volume55
Issue number12
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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