Abstract
Objective: To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the α-synuclein gene is responsible for familial Parkinson disease (PD) in the US population. Design: Polymerase chain reaction-based DNA analysis of consecutive patients with PD and family history of PD. Setting: A university-affiliated movement disorder clinic and a Veterans Affairs clinical research laboratory. Patients: Forty-four patients with PD and family history of PD and 29 patients with sporadic PD, all with no known Greek and/or Italian background. Results: None of the DNA samples showed the G209A mutation. Conclusion: The G209A mutation is rare in US patients with familial PD.
Original language | English (US) |
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Pages (from-to) | 1521-1523 |
Number of pages | 3 |
Journal | Archives of neurology |
Volume | 55 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1998 |
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology