TY - JOUR
T1 - The future of hypertension pharmacotherapy
T2 - Ongoing and future clinical trials for hypertension
AU - Mansoor, Taha
AU - Farrukh, Fatima
AU - Khalid, Subaina N.
AU - Abramov, Dmitry
AU - Michos, Erin D.
AU - Mehta, Anurag
AU - Paul, Timir K.
AU - Dani, Sourbha S.
AU - Al Rifai, Mahmoud
AU - Misra, Arunima
AU - Nambi, Vijay
AU - Virani, Salim S.
AU - Minhas, Abdul Mannan Khan
N1 - Publisher Copyright:
Copyright © 2024 Elsevier Inc. All rights reserved.
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review. We used clinicaltrials.gov to gather information about ongoing clinical trials of pharmacological hypertension therapy as of March 2024 and found 103 clinical trials that met our criteria. The interventions of these 103 clinical trials include novel and previously approved pharmacological and dietary supplement therapies for hypertension. We aim to use these clinical trials to provide insight into the future therapies and practices of hypertension treatment.
AB - Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review. We used clinicaltrials.gov to gather information about ongoing clinical trials of pharmacological hypertension therapy as of March 2024 and found 103 clinical trials that met our criteria. The interventions of these 103 clinical trials include novel and previously approved pharmacological and dietary supplement therapies for hypertension. We aim to use these clinical trials to provide insight into the future therapies and practices of hypertension treatment.
KW - Clinical trials
KW - future
KW - hypertension
KW - pharmacotherapy
KW - Antihypertensive Agents/therapeutic use
KW - Blood Pressure/drug effects
KW - Humans
KW - Clinical Trials as Topic
KW - Renin-Angiotensin System/drug effects
KW - Hypertension/drug therapy
UR - http://www.scopus.com/inward/record.url?scp=85211521421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85211521421&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2024.102922
DO - 10.1016/j.cpcardiol.2024.102922
M3 - Review article
C2 - 39522662
AN - SCOPUS:85211521421
SN - 0146-2806
VL - 50
SP - 102922
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 1
ER -