The function of DNA topoisomerase IIβ in neuronal development

Xin Heng; Wei Dong Le

doi:10.1007/s12264-010-0625-9

The function of DNA topoisomerase IIβ in neuronal development

Xin Heng, Wei Dong Le

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.

Original language	English (US)
Pages (from-to)	411-416
Number of pages	6
Journal	Neuroscience Bulletin
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s12264-010-0625-9
State	Published - Oct 2010

Keywords

Axon guidance
Neuronal development
Neuronal differentiation

ASJC Scopus subject areas

Physiology
Neuroscience(all)

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10.1007/s12264-010-0625-9

Cite this

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title = "The function of DNA topoisomerase IIβ in neuronal development",

abstract = "Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.",

keywords = "Axon guidance, Neuronal development, Neuronal differentiation",

author = "Xin Heng and Le, {Wei Dong}",

note = "Funding Information: Acknowledgements: This work was supported by the National Natural Science Foundation of China (No. 39070925), Shanghai International Science and Technology Cooperation Program (No. 075407066), and National High Technology Research and Development Program of China (No. 2006AA02A408)",

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T1 - The function of DNA topoisomerase IIβ in neuronal development

AU - Heng, Xin

AU - Le, Wei Dong

N1 - Funding Information: Acknowledgements: This work was supported by the National Natural Science Foundation of China (No. 39070925), Shanghai International Science and Technology Cooperation Program (No. 075407066), and National High Technology Research and Development Program of China (No. 2006AA02A408)

PY - 2010/10

Y1 - 2010/10

N2 - Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.

AB - Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.

KW - Axon guidance

KW - Neuronal development

KW - Neuronal differentiation

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The function of DNA topoisomerase IIβ in neuronal development

Abstract

Keywords

ASJC Scopus subject areas

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