TY - JOUR
T1 - The function of DNA topoisomerase IIβ in neuronal development
AU - Heng, Xin
AU - Le, Wei Dong
N1 - Funding Information:
Acknowledgements: This work was supported by the National Natural Science Foundation of China (No. 39070925), Shanghai International Science and Technology Cooperation Program (No. 075407066), and National High Technology Research and Development Program of China (No. 2006AA02A408)
PY - 2010/10
Y1 - 2010/10
N2 - Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.
AB - Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIp in neuronal development over the recent decades.
KW - Axon guidance
KW - Neuronal development
KW - Neuronal differentiation
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U2 - 10.1007/s12264-010-0625-9
DO - 10.1007/s12264-010-0625-9
M3 - Review article
C2 - 20882068
AN - SCOPUS:78650182756
SN - 1673-7067
VL - 26
SP - 411
EP - 416
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
IS - 5
ER -