The function of BAFF on T helper cells in autoimmunity

Maogen Chen, Xiaohong Lin, Ya Liu, Qiang Li, Yiling Deng, Zhongmin Liu, David Brand, Zhiyong Guo, Xiaoshun He, Bernhard Ryffel, Song Guo Zheng

Research output: Contribution to journalShort surveypeer-review

42 Scopus citations

Abstract

B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalCytokine and Growth Factor Reviews
Volume25
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • BAFF
  • T helper cells
  • Tfh cells
  • Th17
  • Treg cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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