The First Case of Ischemia-Free Kidney Transplantation in Humans

Xiaoshun He, Guodong Chen, Zebin Zhu, Zhiheng Zhang, Xiaopeng Yuan, Ming Han, Qiang Zhao, Yitao Zheng, Yunhua Tang, Shanzhou Huang, Linhe Wang, Otto B. van Leeuwen, Xiaoping Wang, Chuanbao Chen, Liqiu Mo, Xingyuan Jiao, Xianchang Li, Changxi Wang, Jiefu Huang, Jun CuiZhiyong Guo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.

Original languageEnglish (US)
Article number276
JournalFrontiers in Medicine
Volume6
DOIs
StatePublished - Dec 11 2019

Keywords

  • ischemia-free kidney transplantation
  • ischemia-free organ transplantation
  • ischemia-reperfusion injury
  • kidney transplantation
  • normothermic machine perfusion

ASJC Scopus subject areas

  • Medicine(all)

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