The Exposome and Cardiovascular Health

Issam Motairek, Mohamed H.E. Makhlouf, Sanjay Rajagopalan, Sadeer Al-Kindi

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The study of the interplay between social factors, environmental hazards, and health has garnered much attention in recent years. The term “exposome“ was coined to describe the total impact of environmental exposures on an individual's health and well-being, serving as a complementary concept to the genome. Studies have shown a strong correlation between the exposome and cardiovascular health, with various components of the exposome having been implicated in the development and progression of cardiovascular disease. These components include the natural and built environment, air pollution, diet, physical activity, and psychosocial stress, among others. This review provides an overview of the relationship between the exposome and cardiovascular health, highlighting the epidemiologic and mechanistic evidence of environmental exposures on cardiovascular disease. The interplay between various environmental components is discussed, and potential avenues for mitigation are identified.

Original languageEnglish (US)
Pages (from-to)1191-1203
Number of pages13
JournalCanadian Journal of Cardiology
Issue number9
StatePublished - Sep 2023

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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