The experimental study of the canine auxiliary partial liver transplantation for the liver failure

J. F. Huang, Xiaoshun He, W. H. Xuan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A model of hepatic failure was established by injection of galactosamine in CCL4-induced liver cirrhosis. Auxiliary partial liver transplantation (APLT) was carried out to treat those dogs. The survival rate, biochemical change patterns, and histologic changes were investigated in both APLT group and control group. The survival rate in APLT and control group was 59.1% and 7.1% respectively, (P < 0.01). Fair supporting graft function was demonstrated by uptake and excretion of 99mTC-HIDA and 99mTC-DIASA at cholescintigraphy, ammonia aetoxification, synthesis of clotting factors and glucohomeostasis. The results indicate that auxiliary transplantation of a partial liver proviae metabolic support and improve survival in animals with hepatic failure. The character of the model, the advantages and the disadvantages of the APLT, were also discussed.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalZhonghua wai ke za zhi [Chinese journal of surgery]
Volume32
Issue number6
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Medicine(all)

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