24 Scopus citations


Exosome complexes are compo′sed of 10 to 11 subunits and are involved in multiple facets of 39-59 RNA processing and turnover. The current paradigm stipulates that a uniform, stoichiometric core exosome, composed of single copies of each subunit, carries out all RNA metabolic functions in vivo. While core composition is well established in vitro, available genetic, cell biological, proteomic, and transcriptomic data raise questions about whether individual subunits contribute to RNA metabolic functions exclusively within the complex. Here, we recount the current understanding of the core exosome model and show predictions of the core model that are not satisfied by the available evidence. To resolve this discrepancy, we propose the exozyme hypothesis, a novel model stipulating that while exosome subunits can and do carry out certain functions within the core, subsets of exosome subunits and cofactors also assemble into a continuum of compositionally distinct complexes- exozymes-with different RNA specificities. The exozyme model is consistent with all published data and provides a new framework for understanding the general mechanisms and regulation of RNA processing and turnover.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
Issue number1
StatePublished - Jan 2011


  • Dis3
  • Exosome
  • Exosome subunit
  • Exozyme
  • RNA processing
  • RNA surveillance
  • RNA turnover
  • Ribonuclease
  • Rrp6

ASJC Scopus subject areas

  • Molecular Biology


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