The evolving role of mTOR inhibition in transplantation tolerance

Gearoid McMahon, Matthew R. Weir, Xian C. Li, Didier A. Mandelbrot

Research output: Contribution to journalShort survey

32 Scopus citations

Abstract

The mammalian target of rapamycin (mTOR) plays a key role in the immune response. mTOR inhibitors suppress T cell activation and proliferation and are effective immunosuppressants. Today there is growing interest in their potential role in inducing tolerance after transplantation. mTOR inhibitors induce anergy in naïve T cells, promote the expansion of regulatory T cells, and inhibit the maturation of dendritic cells, thus promoting immunologic tolerance. Here we review the mechanisms by which mTOR inhibitors promote tolerance. We discuss the clinical relevance of these mechanisms and suggest how they might be used in the design of future protocols to induce tolerance.

Original languageEnglish (US)
Pages (from-to)408-415
Number of pages8
JournalJournal of the American Society of Nephrology
Volume22
Issue number3
DOIs
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Nephrology

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