The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis

Keva Garg, Toral R. Patel, Arjun Kanwal, Todd C. Villines, Niti R. Aggarwal, Khurram Nasir, Roger S. Blumenthal, Michael J. Blaha, Pamela S. Douglas, Leslee J. Shaw, Garima Sharma

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnostic test for women, especially as we continue to understand the impact of non-obstructive atherosclerosis as well as diffuse, high risk plaque as precursors of acute cardiac events in women. Based on its ability to identify complex plaque morphology such as low attenuation plaque, high risk non calcified plaque, positive remodeling, fibrous cap, CCTA can be used to assess plaque characteristics. CCTA can avoid false positive of other imaging studies, if included earlier in assessment of ischemic symptoms. In the contemporary clinical setting, CCTA will prove useful in further understanding and managing cardiovascular disease in women and those without traditional obstructive coronary disease.

Original languageEnglish (US)
Pages (from-to)138-149
Number of pages12
JournalJournal of cardiovascular computed tomography
Issue number2
StatePublished - Mar 1 2022


  • And cardiac computed tomography
  • Atherosclerosis
  • Cardiovascular disease
  • Ischemic heart disease
  • Sex
  • Sex disparities
  • Women
  • Predictive Value of Tests
  • Humans
  • Male
  • Tomography, X-Ray Computed
  • Sex Characteristics
  • Plaque, Atherosclerotic
  • Computed Tomography Angiography
  • Coronary Artery Disease/diagnostic imaging
  • Female
  • Coronary Angiography/methods

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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