The Evolution of Mechanical Circulatory Support

Ju H. Kim; Jennifer A. Cowger; Palak Shah

doi:10.1016/j.ccl.2018.06.011

The Evolution of Mechanical Circulatory Support

Ju H. Kim, Jennifer A. Cowger, Palak Shah

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The field of mechanical circulatory support (MCS) has evolved from earlier-generation pulsatile-flow devices that were primarily used to support critically ill patients in the hospital to newer-generation continuous-flow devices that permit hospital discharge and resumption of normal life activities. The technology is used to bridge transplant-eligible patients and can be used for long-term support of patients who are transplant ineligible. Left ventricular assist devices are proved to improve long-term survival and quality of life for patients with advanced heart failure. Adverse events associated with MCS therapy remain the Achilles heel of the field and strategies to improve biocompatibility are ongoing.

Original language	English (US)
Pages (from-to)	443-449
Number of pages	7
Journal	Cardiology Clinics
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.ccl.2018.06.011
State	Published - Nov 2018

Keywords

Cardiac transplantation
Heart failure
Mechanical circulatory support
Total artificial heart
Ventricular assist device

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ccl.2018.06.011

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title = "The Evolution of Mechanical Circulatory Support",

abstract = "The field of mechanical circulatory support (MCS) has evolved from earlier-generation pulsatile-flow devices that were primarily used to support critically ill patients in the hospital to newer-generation continuous-flow devices that permit hospital discharge and resumption of normal life activities. The technology is used to bridge transplant-eligible patients and can be used for long-term support of patients who are transplant ineligible. Left ventricular assist devices are proved to improve long-term survival and quality of life for patients with advanced heart failure. Adverse events associated with MCS therapy remain the Achilles heel of the field and strategies to improve biocompatibility are ongoing.",

keywords = "Cardiac transplantation, Heart failure, Mechanical circulatory support, Total artificial heart, Ventricular assist device",

author = "Kim, {Ju H.} and Cowger, {Jennifer A.} and Palak Shah",

note = "Funding Information: Disclosure Statement: J.H. Kim—no disclosures; J.A. Cowger—reports institutional research and speaking for Abbott, institutional research, steering committee, and paid speaking for HeartWare ; P. Shah reports grant support from Merck , Haemonetics , and an AHA Scientist Development Award cofunded by the Enduring Hearts Foundation (17SDG33660431) . Funding Information: Disclosure Statement: J.H. Kim—no disclosures; J.A. Cowger—reports institutional research and speaking for Abbott, institutional research, steering committee, and paid speaking for HeartWare; P. Shah reports grant support from Merck, Haemonetics, and an AHA Scientist Development Award cofunded by the Enduring Hearts Foundation (17SDG33660431). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = nov,

doi = "10.1016/j.ccl.2018.06.011",

language = "English (US)",

volume = "36",

pages = "443--449",

journal = "Cardiology Clinics",

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publisher = "W.B. Saunders Ltd",

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AU - Kim, Ju H.

AU - Cowger, Jennifer A.

AU - Shah, Palak

N1 - Funding Information: Disclosure Statement: J.H. Kim—no disclosures; J.A. Cowger—reports institutional research and speaking for Abbott, institutional research, steering committee, and paid speaking for HeartWare ; P. Shah reports grant support from Merck , Haemonetics , and an AHA Scientist Development Award cofunded by the Enduring Hearts Foundation (17SDG33660431) . Funding Information: Disclosure Statement: J.H. Kim—no disclosures; J.A. Cowger—reports institutional research and speaking for Abbott, institutional research, steering committee, and paid speaking for HeartWare; P. Shah reports grant support from Merck, Haemonetics, and an AHA Scientist Development Award cofunded by the Enduring Hearts Foundation (17SDG33660431). Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/11

Y1 - 2018/11

N2 - The field of mechanical circulatory support (MCS) has evolved from earlier-generation pulsatile-flow devices that were primarily used to support critically ill patients in the hospital to newer-generation continuous-flow devices that permit hospital discharge and resumption of normal life activities. The technology is used to bridge transplant-eligible patients and can be used for long-term support of patients who are transplant ineligible. Left ventricular assist devices are proved to improve long-term survival and quality of life for patients with advanced heart failure. Adverse events associated with MCS therapy remain the Achilles heel of the field and strategies to improve biocompatibility are ongoing.

AB - The field of mechanical circulatory support (MCS) has evolved from earlier-generation pulsatile-flow devices that were primarily used to support critically ill patients in the hospital to newer-generation continuous-flow devices that permit hospital discharge and resumption of normal life activities. The technology is used to bridge transplant-eligible patients and can be used for long-term support of patients who are transplant ineligible. Left ventricular assist devices are proved to improve long-term survival and quality of life for patients with advanced heart failure. Adverse events associated with MCS therapy remain the Achilles heel of the field and strategies to improve biocompatibility are ongoing.

KW - Cardiac transplantation

KW - Heart failure

KW - Mechanical circulatory support

KW - Total artificial heart

KW - Ventricular assist device

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The Evolution of Mechanical Circulatory Support

Abstract

Keywords

ASJC Scopus subject areas

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