The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model

Eleftherios Mylonakis; Michael Engelbert; Xiang Qin; Costi D. Sifri; Barbara E. Murray; Frederick M. Ausubel; Michael S. Gilmore; Stephen B. Calderwood

doi:10.1128/IAI.70.8.4678-4681.2002

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model

Eleftherios Mylonakis, Michael Engelbert, Xiang Qin, Costi D. Sifri, Barbara E. Murray, Frederick M. Ausubel, Michael S. Gilmore, Stephen B. Calderwood

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92 Scopus citations

Abstract

We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.

Original language	English (US)
Pages (from-to)	4678-4681
Number of pages	4
Journal	Infection and Immunity
Volume	70
Issue number	8
DOIs	https://doi.org/10.1128/IAI.70.8.4678-4681.2002
State	Published - 2002

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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Mylonakis, E., Engelbert, M., Qin, X., Sifri, C. D., Murray, B. E., Ausubel, F. M., Gilmore, M. S., & Calderwood, S. B. (2002). The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model. Infection and Immunity, 70(8), 4678-4681. https://doi.org/10.1128/IAI.70.8.4678-4681.2002

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abstract = "We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.",

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AU - Mylonakis, Eleftherios

AU - Engelbert, Michael

AU - Qin, Xiang

AU - Sifri, Costi D.

AU - Murray, Barbara E.

AU - Ausubel, Frederick M.

AU - Gilmore, Michael S.

AU - Calderwood, Stephen B.

PY - 2002

Y1 - 2002

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AB - We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.

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The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model

Abstract

ASJC Scopus subject areas

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