The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model

Eleftherios Mylonakis, Michael Engelbert, Xiang Qin, Costi D. Sifri, Barbara E. Murray, Frederick M. Ausubel, Michael S. Gilmore, Stephen B. Calderwood

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.

Original languageEnglish (US)
Pages (from-to)4678-4681
Number of pages4
JournalInfection and Immunity
Volume70
Issue number8
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model'. Together they form a unique fingerprint.

Cite this