TY - JOUR
T1 - The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model
AU - Mylonakis, Eleftherios
AU - Engelbert, Michael
AU - Qin, Xiang
AU - Sifri, Costi D.
AU - Murray, Barbara E.
AU - Ausubel, Frederick M.
AU - Gilmore, Michael S.
AU - Calderwood, Stephen B.
PY - 2002
Y1 - 2002
N2 - We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.
AB - We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.
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U2 - 10.1128/IAI.70.8.4678-4681.2002
DO - 10.1128/IAI.70.8.4678-4681.2002
M3 - Article
C2 - 12117982
AN - SCOPUS:0036076721
SN - 0019-9567
VL - 70
SP - 4678
EP - 4681
JO - Infection and Immunity
JF - Infection and Immunity
IS - 8
ER -