The emergence of cefiderocol resistance in 
        Pseudomonas aeruginosa from a heteroresistant isolate during prolonged therapy.

Nicholas Teran; Stephanie L Egge; Kady Phe; Rodrigo P Baptista; Vincent H Tam; William R Miller

doi:10.1128/aac.01009-23

The emergence of cefiderocol resistance in Pseudomonas aeruginosa from a heteroresistant isolate during prolonged therapy.

Nicholas Teran, Stephanie L Egge, Kady Phe, Rodrigo P Baptista, Vincent H Tam, William R Miller

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cefiderocol is a siderophore cephalosporin designed to target multi-drug-resistant Gram-negative bacteria. Previously, the emergence of cefiderocol non-susceptibility has been associated with mutations in the chromosomal cephalosporinase (PDC) along with mutations in the PirA and PiuA/D TonB-dependent receptor pathways. Here, we report a clinical case of cefiderocol-resistant P. aeruginosa that emerged in a patient during treatment. This resistance was associated with mutations not previously reported, suggesting potential novel pathways to cefiderocol resistance.

Original language	English (US)
Pages (from-to)	e0100923
Journal	Antimicrobial Agents and Chemotherapy
Volume	68
Issue number	1
Early online date	Dec 8 2023
DOIs	https://doi.org/10.1128/aac.01009-23
State	Published - Jan 10 2024

Keywords

cefiderocol
Gram-negative bacteria
Pseudomonas aeruginosa
siderophores
gram-negative bacteria
Gram-Negative Bacteria
Humans
Drug Resistance, Multiple, Bacterial/genetics
Cefiderocol
Monobactams/pharmacology
Anti-Bacterial Agents/pharmacology
Microbial Sensitivity Tests
Cephalosporins/pharmacology
Pseudomonas Infections/drug therapy

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/aac.01009-23

Cite this

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title = "The emergence of cefiderocol resistance in Pseudomonas aeruginosa from a heteroresistant isolate during prolonged therapy.",

abstract = "Cefiderocol is a siderophore cephalosporin designed to target multi-drug-resistant Gram-negative bacteria. Previously, the emergence of cefiderocol non-susceptibility has been associated with mutations in the chromosomal cephalosporinase (PDC) along with mutations in the PirA and PiuA/D TonB-dependent receptor pathways. Here, we report a clinical case of cefiderocol-resistant P. aeruginosa that emerged in a patient during treatment. This resistance was associated with mutations not previously reported, suggesting potential novel pathways to cefiderocol resistance. ",

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