The efficacy and safety of transradial and transfemoral approach in treatment of coronary chronic total occlusion: a systematic review and meta-analysis

Mohamad Soud, Ziad SayedAhmad, Marvin Kajy, Fares Alahdab, Fahed Darmoch, Yasser Al-Khadra, Homam Moussa Pacha, Yasar Sattar, Waqas Ullah, Fred King, Ali Bani Saad, Ghaith Alhatemi, Zaher Hakim, Omar E. Ali, James J. Glazier, M. Chadi Alraies

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The clinical efficacy and safety of transradial (TR) percutaneous coronary intervention (PCI) in comparison to transfemoral (TF) for chronic total occlusion (CTO) is not well studied in literature. Objectives: We sought to study the outcome and complications associated with TR compared with TF for CTO interventions. Methods: After a systematic literature search was done in PubMed and EMBASE, we performed a meta-analysis of studies comparing TF and TR for CTO PCI. Results: Twelve studies with 19,309 patients were included. Compared to those who has TF access, individuals who were treated via TR approach had statistically significant lower access complication rates [odds ratio (OR): 0.33; 95% confidence interval (CI): 0.22 to 0.49; p < 0.0001]. The procedural success was in the favor of TR method (OR: 1.4; 95% CI: 1.31–1. 51; p < 0.0001). The incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and contrast-induced nephropathy were similar in both groups. Conclusion: When compared with TF access interventions in CTO PCI; the TR approach appears to be associated with far less access-site complications, higher procedural success, and comparable MACCE.

Original languageEnglish (US)
Pages (from-to)809-817
Number of pages9
JournalExpert Review of Cardiovascular Therapy
Volume18
Issue number11
DOIs
StatePublished - 2020

Keywords

  • Chronic total occlusion
  • percutaneous coronary intervention
  • transfemoral access
  • transradial access
  • vascular complication

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'The efficacy and safety of transradial and transfemoral approach in treatment of coronary chronic total occlusion: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this