The effects of methylglyoxal on central synaptic transmission in the isolated nerve cord of the cockroach. (Periplaneta americana L).

P. L. Chambers; M. G. Davies; M. J. Rowan

doi:10.1007/978-3-642-69928-3_67

The effects of methylglyoxal on central synaptic transmission in the isolated nerve cord of the cockroach. (Periplaneta americana L).

P. L. Chambers, M. G. Davies, M. J. Rowan

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Abstract

Methylglyoxal (10(-5) to 1.5 X 10(-4) M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.

Original language	English (US)
Pages (from-to)	337-341
Number of pages	5
Journal	Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement
Volume	8
DOIs	https://doi.org/10.1007/978-3-642-69928-3_67
State	Published - 1985

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General Medicine

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abstract = "Methylglyoxal (10(-5) to 1.5 X 10(-4) M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.",

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N2 - Methylglyoxal (10(-5) to 1.5 X 10(-4) M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.

AB - Methylglyoxal (10(-5) to 1.5 X 10(-4) M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.

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ER -

The effects of methylglyoxal on central synaptic transmission in the isolated nerve cord of the cockroach. (Periplaneta americana L).

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