TY - JOUR
T1 - The effect of various centrally-acting drugs on hepatic steroid metabolism in male and female rats
AU - Skett, Paul
AU - Mode, Agneta
AU - Eneroth, Peter
AU - Gustafsson, Jan Åke
N1 - Funding Information:
Acknowledgements-Thisi nvestigationw as supportedb y a grant from The Swedish Medical ResearchC ouncil (No. 13X-281 9).A . M. is gratefutl o StiftelsenB engtL undqvists Minne for a fellowship.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1979/3/15
Y1 - 1979/3/15
N2 - The effects of various centrally-acting drugs on steroid metabolism in the liver and pituitary hormone concentration in the serum of male and female rats were investigated using well characterized and tested methods. It was seen that picrotoxin, morphine and LSD had a general stimulatory action on hepatic steroid metabolism (morphine only in the female) whereas thiosemicarbazide was without effect. Clonidine gave a move towards a more "female" type of metabolism in the male animals. All drugs tested except thiosemicarbazide had effects on pituitary hormone secretion although not always the effects that have been previously reported. Discrepancies from previous reports are discussed. Correlations between changes in hepatic steroid metabolism and changes in pituitary hormone secretion can be observed but are not consistent. It is concluded that, of the drugs tested, only clonidine may have an effect on "feminizing factor" secretion indicating that this may be controlled in part by the noradrenergic system of the brain.
AB - The effects of various centrally-acting drugs on steroid metabolism in the liver and pituitary hormone concentration in the serum of male and female rats were investigated using well characterized and tested methods. It was seen that picrotoxin, morphine and LSD had a general stimulatory action on hepatic steroid metabolism (morphine only in the female) whereas thiosemicarbazide was without effect. Clonidine gave a move towards a more "female" type of metabolism in the male animals. All drugs tested except thiosemicarbazide had effects on pituitary hormone secretion although not always the effects that have been previously reported. Discrepancies from previous reports are discussed. Correlations between changes in hepatic steroid metabolism and changes in pituitary hormone secretion can be observed but are not consistent. It is concluded that, of the drugs tested, only clonidine may have an effect on "feminizing factor" secretion indicating that this may be controlled in part by the noradrenergic system of the brain.
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U2 - 10.1016/0006-2952(79)90347-2
DO - 10.1016/0006-2952(79)90347-2
M3 - Article
C2 - 454470
AN - SCOPUS:0018764810
SN - 0006-2952
VL - 28
SP - 719
EP - 722
JO - Biochemical pharmacology
JF - Biochemical pharmacology
IS - 6
ER -