The effect of solutions' concentration on diffusion in scleral tissues

Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui, Valery V. Tuchin, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


The calculation of permeability coefficient of analytes could potentially be used in a variety of basic science and clinical fields, as well as advanced diagnostic imaging. Before this can occur, a more thorough understanding of the diffusion rate of analytes in biological tissues is needed. For this task, we utilized Optical Coherence Tomography for the functional imaging of glucose diffusion through rabbit sclera tissues. The permeability coefficients were calculated for different concentrations of glucose solution as they diffused through the tissue. From the experiments performed it was noticed that the concentration of the analyte was inversely proportional to the permeability coefficient calculated. The permeability coefficient of glucose solution with lower concentration was faster when compared with higher concentration. The decrease in the permeability coefficient ranged from (1.67 ± 0.17) × 10 -5 cm/sec with the 10% glucose solution to (5.08 ± 0.23) 7times; 10 -6 cm/sec of 25% glucose solution. The results of this study could expand the use of the permeability coefficient into the field of diagnostic imaging.

Original languageEnglish (US)
Title of host publicationSaratov Fall Meeting 2007
Subtitle of host publicationOptical Technologies in Biophysics and Medicine IX
StatePublished - 2008
EventSaratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX - Saratov, Russian Federation
Duration: Sep 25 2007Sep 28 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSaratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Country/TerritoryRussian Federation


  • Eye sclera
  • Glucose diffusion
  • Light scattering
  • OCT
  • Permeability coefficient

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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