The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

F. Gentile; C. Chiappini; D. Fine; R. C. Bhavane; M. S. Peluccio; M. Ming Cheng Cheng; X. Liu; Mauro Ferrari; P. Decuzzi

doi:10.1016/j.jbiomech.2008.03.021

The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

F. Gentile, C. Chiappini, D. Fine, R. C. Bhavane, M. S. Peluccio, M. Ming Cheng Cheng, X. Liu, Mauro Ferrari, P. Decuzzi

Houston Methodist Hospital

Research output: Contribution to journal › Article › peer-review

265 Scopus citations

Abstract

The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S^-0.63 for the spheres; S^-0.85 for discoidal and S^-1 for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.

Original language	English (US)
Pages (from-to)	2312-2318
Number of pages	7
Journal	Journal of Biomechanics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1016/j.jbiomech.2008.03.021
State	Published - Jul 19 2008

Keywords

Drug delivery
Fluidic chamber
Particle dynamics
Sedimentation

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Rehabilitation
Biophysics
Biomedical Engineering

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10.1016/j.jbiomech.2008.03.021

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title = "The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows",

abstract = "The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S-0.63 for the spheres; S-0.85 for discoidal and S-1 for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.",

keywords = "Drug delivery, Fluidic chamber, Particle dynamics, Sedimentation",

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AU - Gentile, F.

AU - Chiappini, C.

AU - Fine, D.

AU - Bhavane, R. C.

AU - Peluccio, M. S.

AU - Cheng, M. Ming Cheng

AU - Liu, X.

AU - Ferrari, Mauro

AU - Decuzzi, P.

PY - 2008/7/19

Y1 - 2008/7/19

N2 - The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S-0.63 for the spheres; S-0.85 for discoidal and S-1 for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.

AB - The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S-0.63 for the spheres; S-0.85 for discoidal and S-1 for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.

KW - Drug delivery

KW - Fluidic chamber

KW - Particle dynamics

KW - Sedimentation

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The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

Abstract

Keywords

ASJC Scopus subject areas

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