The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

F. Gentile, C. Chiappini, D. Fine, R. C. Bhavane, M. S. Peluccio, M. Ming Cheng Cheng, X. Liu, Mauro Ferrari, P. Decuzzi

Research output: Contribution to journalArticle

215 Scopus citations

Abstract

The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S-0.63 for the spheres; S-0.85 for discoidal and S-1 for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.

Original languageEnglish (US)
Pages (from-to)2312-2318
Number of pages7
JournalJournal of Biomechanics
Volume41
Issue number10
DOIs
StatePublished - Jul 19 2008

Keywords

  • Drug delivery
  • Fluidic chamber
  • Particle dynamics
  • Sedimentation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

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