TY - GEN
T1 - The effect of pulsed HIFU on the porosity and permeability of collagen gels
T2 - 11th International Symposium on Therapeutic Ultrasound, ISTU 2011
AU - Vipulanandan, Geethanjali
AU - O'Neill, Brian E.
PY - 2012
Y1 - 2012
N2 - Pulsed HIFU is hypothesized to alter permeability of the extracellular matrix by altering the collagen network. In this study, the ability of HIFU to disrupt the extracellular matrix, particularly Type I collagen, in vitro, was investigated in order to enhance the drug delivery to highly collagenous tumors. This was tested in vitro in two ways, first using dye penetration, and second, by confocal reflection microscopy. Based on the analyses, it was concluded that there was at least a three-fold increase in porosity of the collagen gels after HIFU treatment.
AB - Pulsed HIFU is hypothesized to alter permeability of the extracellular matrix by altering the collagen network. In this study, the ability of HIFU to disrupt the extracellular matrix, particularly Type I collagen, in vitro, was investigated in order to enhance the drug delivery to highly collagenous tumors. This was tested in vitro in two ways, first using dye penetration, and second, by confocal reflection microscopy. Based on the analyses, it was concluded that there was at least a three-fold increase in porosity of the collagen gels after HIFU treatment.
UR - http://www.scopus.com/inward/record.url?scp=84873165137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873165137&partnerID=8YFLogxK
U2 - 10.1063/1.4757370
DO - 10.1063/1.4757370
M3 - Conference contribution
AN - SCOPUS:84873165137
SN - 9780735410930
T3 - AIP Conference Proceedings
SP - 414
EP - 418
BT - 11th International Symposium on Therapeutic Ultrasound
Y2 - 11 April 2011 through 13 April 2011
ER -