The effect of pulsed HIFU on the porosity and permeability of collagen gels: An in vitro study

Geethanjali Vipulanandan, Brian E. O'Neill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pulsed HIFU is hypothesized to alter permeability of the extracellular matrix by altering the collagen network. In this study, the ability of HIFU to disrupt the extracellular matrix, particularly Type I collagen, in vitro, was investigated in order to enhance the drug delivery to highly collagenous tumors. This was tested in vitro in two ways, first using dye penetration, and second, by confocal reflection microscopy. Based on the analyses, it was concluded that there was at least a three-fold increase in porosity of the collagen gels after HIFU treatment.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Pages414-418
Number of pages5
DOIs
StatePublished - 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
Volume1481
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Symposium on Therapeutic Ultrasound, ISTU 2011
CountryUnited States
CityNew York, NY
Period4/11/114/13/11

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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