The effect of pulsed HIFU on the porosity and permeability of collagen gels: An in vitro study

Geethanjali Vipulanandan; Brian E. O'Neill

doi:10.1063/1.4757370

The effect of pulsed HIFU on the porosity and permeability of collagen gels: An in vitro study

Geethanjali Vipulanandan, Brian E. O'Neill

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Pulsed HIFU is hypothesized to alter permeability of the extracellular matrix by altering the collagen network. In this study, the ability of HIFU to disrupt the extracellular matrix, particularly Type I collagen, in vitro, was investigated in order to enhance the drug delivery to highly collagenous tumors. This was tested in vitro in two ways, first using dye penetration, and second, by confocal reflection microscopy. Based on the analyses, it was concluded that there was at least a three-fold increase in porosity of the collagen gels after HIFU treatment.

Original language	English (US)
Title of host publication	11th International Symposium on Therapeutic Ultrasound
Pages	414-418
Number of pages	5
DOIs	https://doi.org/10.1063/1.4757370
State	Published - 2012
Event	11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States Duration: Apr 11 2011 → Apr 13 2011

Publication series

Name	AIP Conference Proceedings
Volume	1481
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Other

Other	11th International Symposium on Therapeutic Ultrasound, ISTU 2011
Country	United States
City	New York, NY
Period	4/11/11 → 4/13/11

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1063/1.4757370

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Vipulanandan, G & O'Neill, BE 2012, The effect of pulsed HIFU on the porosity and permeability of collagen gels: An in vitro study. in 11th International Symposium on Therapeutic Ultrasound. AIP Conference Proceedings, vol. 1481, pp. 414-418, 11th International Symposium on Therapeutic Ultrasound, ISTU 2011, New York, NY, United States, 4/11/11. https://doi.org/10.1063/1.4757370

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AB - Pulsed HIFU is hypothesized to alter permeability of the extracellular matrix by altering the collagen network. In this study, the ability of HIFU to disrupt the extracellular matrix, particularly Type I collagen, in vitro, was investigated in order to enhance the drug delivery to highly collagenous tumors. This was tested in vitro in two ways, first using dye penetration, and second, by confocal reflection microscopy. Based on the analyses, it was concluded that there was at least a three-fold increase in porosity of the collagen gels after HIFU treatment.

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