The effect of pregnancy on cyclosporine levels in renal allograft patients

Albert George Thomas, Lewis Burrows, Richard Knight, Mary Panico, Robert Lapinski, Charles J. Lockwood

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Objective: To assess the effects of pregnancy on cyclosporine levels in six renal allograft patients. Methods: Maternal demographic, laboratory, clinical, and perinatal outcome data were recorded in six pregnant women with previous renal allografts receiving cyclosporine immunosuppression. The cyclosporine and serum creatinine levels were measured before pregnancy, during each trimester, and postpartum. Results: The mean (standard deviation [SD]) maternal age was 29.1 (3.8) years. Parity ranged from 0 to 3. Mean serum creatinine levels tended to be lower during pregnancy than before or after, as did the mean cyclosporine levels. After adjusting for dose, five of six patients had declines in cyclosporine level during pregnancy. The mean (SD) gestational age at delivery was 37.5 (2.8) weeks with a mean (SD) birth weight of 2837 (538) g. Conclusion: Pregnancy in patients with renal allografts can lead to a substantial decline in cyclosporine levels.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalObstetrics and Gynecology
Volume90
Issue number6
DOIs
StatePublished - Dec 1997

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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