Abstract
In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-126 |
| Number of pages | 6 |
| Journal | International Journal of Pharmaceutics |
| Volume | 68 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Feb 1 1991 |
Keywords
- Bone marrow
- Liposome
- Photon correlation spectroscopy
- Poloxamer
- Reticuloendothelial system
ASJC Scopus subject areas
- Pharmaceutical Science
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