TY - JOUR
T1 - The effect of poloxamer-407 on liposome stability and targeting to bone marrow
T2 - comparison with polystyrene microspheres
AU - Moghimi, Seyed
AU - Porter, C. J.H.
AU - Illum, L.
AU - Davis, S. S.
PY - 1991/2/1
Y1 - 1991/2/1
N2 - In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.
AB - In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.
KW - Bone marrow
KW - Liposome
KW - Photon correlation spectroscopy
KW - Poloxamer
KW - Reticuloendothelial system
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U2 - 10.1016/0378-5173(91)90134-A
DO - 10.1016/0378-5173(91)90134-A
M3 - Article
AN - SCOPUS:0026081696
VL - 68
SP - 121
EP - 126
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-3
ER -