Vliianie ligandov opiatnykh retseptorov na émotsiogennye reaktsii serdechno-sosudistoǐ sistemy u nizshikh primatov.

Translated title of the contribution: The effect of opiate receptor ligands on emotional cardiovascular reactions in lower primates

Eugene V. Golanov, A. A. Fufacheva, G. M. Cherkovich, S. B. Parin

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Intravenous naloxone injection (0.1 mg/kg) facilitated blood pressure increase in response to conditioned sound stimulus followed by electrocutaneous shock in conscious chair-restrained baboons (Papio hamadryas). Naloxone at a dose of 1.0 mg/kg had an opposite effect and led to the decrease in blood pressure and heart rate in conditioned fear reflex. Naloxone microinjections (50 microM) into the periventricular hypothalamus led to a significant diminution of blood pressure and heart rate increment in response to electrocutaneous shock; naloxone microinjections into tractus solitarius nuclei suppressed blood pressure and heart rate reactions both to conditioned (sound) and unconditioned (electrocutaneous shock) stimuli. Microinjections of equimolar morphine quantities in these brain regions facilitated such reactions. It is concluded that endogenous opioid system participates in the formation of cardiovascular reactions to emotional stimuli in monkeys, with multiple opioid receptors of periventricular hypothalamus and tractus solitarius nuclei involved in the generation of such reactions.

Translated title of the contributionThe effect of opiate receptor ligands on emotional cardiovascular reactions in lower primates
Original languageRussian
Pages (from-to)424-427
Number of pages4
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume103
Issue number4
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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