The effect of marital status on stage and survival of prostate cancer patients treated with radical prostatectomy: A population-based study

Firas Abdollah, Maxine Sun, Rodolphe Thuret, Al'a Abdo, Monica Morgan, Claudio Jeldres, Shahrokh F. Shariat, Paul Perrotte, Francesco Montorsi, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Objective: The detrimental effect of unmarried marital status on stage and survival has been confirmed in several malignancies. We set to test whether this applied to patients diagnosed with prostate cancer (PCa) treated with radical prostatectomy (RP). Methods: We identified 163,697 non-metastatic PCa patients treated with RP, within 17 Surveillance, Epidemiology, and End Results registries. Logistic regression analyses focused on the rate of locally advanced stage (pT3-4/pN1) at RP. Cox regression analyses tested the relationship between marital status and cancer-specific (CSM), as well as all-cause mortality (ACM). Results: Respectively, 9.1 and 7.8% of individuals were separated/divorced/widowed (SDW) and never married. SDW men had more advanced stage at surgery (odds ratio: 1.1; p<0.001), higher CSM and ACM (both hazard ratio [HR]: 1.3; p<0.001) than married men. Similarly, never married marital status portended to a higher ACM rate (HR:1.2, p = 0.001). These findings were consistent when analyses were stratified according to organ confined vs. locally advanced stages. Conclusions: Being SDW significantly increased the risk of more advanced stage at RP. Following surgery, SDW men portended to a higher CSM and ACM rate than married men. Consequently, these individuals may benefit from a more focused health care throughout the natural history of their disease.

Original languageEnglish (US)
Pages (from-to)1085-1095
Number of pages11
JournalCancer Causes and Control
Volume22
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • Marital status
  • Neoplasm staging
  • Prostatic neoplasms/epidemiology
  • SEER program
  • Survival rates/trends

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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