TY - JOUR
T1 - The effect of ketorolac on postoperative febrile episodes in patients after abdominal myomectomy
AU - Held, Barbara I.
AU - Michels, Anne
AU - Blanco, Jody
AU - Ascher-Walsh, Charles
AU - Strohbehn, Kris
PY - 2002/12/1
Y1 - 2002/12/1
N2 - OBJECTIVE: Our purpose was to determine whether administering the anti-inflammatory agent ketorolac after abdominal myomectomy reduces the incidence of febrile episodes. STUDY DESIGN: This prospective, randomized, double-blinded, placebo-controlled clinical investigation compared administering ketorolac 15 mg intravenously every 6 hours beginning in the recovery room with saline solution administered in the same regimen in 122 patients undergoing abdominal myomectomy in a large, urban academic medical center. The primary outcome was fever >101.0°F in the postoperative period. Results were analyzed by X2 analysis, independent samples t test, and logistic regression. RESULTS: Data were analyzed on 112 patients, with 56 in the treatment group and 56 in the placebo group. After confounding factors were controlled with logistic regression, the data revealed a statistically significant reduction in febrile episodes in the ketorolac-treated group (27%) compared with the saline solution-treated group (41%) (P = .04). CONCLUSION: Treatment with ketorolac after abdominal myomectomy results in a statistically significant reduction in the rate of febrile episodes.
AB - OBJECTIVE: Our purpose was to determine whether administering the anti-inflammatory agent ketorolac after abdominal myomectomy reduces the incidence of febrile episodes. STUDY DESIGN: This prospective, randomized, double-blinded, placebo-controlled clinical investigation compared administering ketorolac 15 mg intravenously every 6 hours beginning in the recovery room with saline solution administered in the same regimen in 122 patients undergoing abdominal myomectomy in a large, urban academic medical center. The primary outcome was fever >101.0°F in the postoperative period. Results were analyzed by X2 analysis, independent samples t test, and logistic regression. RESULTS: Data were analyzed on 112 patients, with 56 in the treatment group and 56 in the placebo group. After confounding factors were controlled with logistic regression, the data revealed a statistically significant reduction in febrile episodes in the ketorolac-treated group (27%) compared with the saline solution-treated group (41%) (P = .04). CONCLUSION: Treatment with ketorolac after abdominal myomectomy results in a statistically significant reduction in the rate of febrile episodes.
KW - Ketorolac
KW - Myomectomy
KW - Operative complications
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U2 - 10.1067/mob.2002.130006
DO - 10.1067/mob.2002.130006
M3 - Article
C2 - 12501045
AN - SCOPUS:0036910363
SN - 0002-9378
VL - 187
SP - 1450
EP - 1455
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 6
ER -