The effect of ketorolac on postoperative febrile episodes in patients after abdominal myomectomy

Barbara I. Held, Anne Michels, Jody Blanco, Charles Ascher-Walsh, Kris Strohbehn

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

OBJECTIVE: Our purpose was to determine whether administering the anti-inflammatory agent ketorolac after abdominal myomectomy reduces the incidence of febrile episodes. STUDY DESIGN: This prospective, randomized, double-blinded, placebo-controlled clinical investigation compared administering ketorolac 15 mg intravenously every 6 hours beginning in the recovery room with saline solution administered in the same regimen in 122 patients undergoing abdominal myomectomy in a large, urban academic medical center. The primary outcome was fever >101.0°F in the postoperative period. Results were analyzed by X2 analysis, independent samples t test, and logistic regression. RESULTS: Data were analyzed on 112 patients, with 56 in the treatment group and 56 in the placebo group. After confounding factors were controlled with logistic regression, the data revealed a statistically significant reduction in febrile episodes in the ketorolac-treated group (27%) compared with the saline solution-treated group (41%) (P = .04). CONCLUSION: Treatment with ketorolac after abdominal myomectomy results in a statistically significant reduction in the rate of febrile episodes.

Original languageEnglish (US)
Pages (from-to)1450-1455
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume187
Issue number6
DOIs
StatePublished - Dec 1 2002

Keywords

  • Ketorolac
  • Myomectomy
  • Operative complications

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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