TY - JOUR
T1 - The Effect of Intestinal Microflora on the Enterohepatic Circulation of Mercapturic Acid Pathway Metabolites
AU - Gustafsson, Jan-Ake
AU - Ratter, Joseph J.
AU - Bakke, Jerome E.
AU - Gustafsson, Bengt E.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The metabolism of four xenobiotics, pentachloromethylthiobenzene, 2 chloro-n-isopropylacetanilide, 2-acetamido-4- (chloromethyl) thiazole and 2,4',5-trichlorobiphenyl, which are known to be metabolized via the mercapturic acid pathway, was examined in germfree and conventional rats. An essential role for the intestinal flora in the metabolism of the above compounds and in the production of certain metabolites was established. Mechanisms for the formation of these latter metabolites from the mercapturates are proposed. These mechanisms involve enterohepatic circulation and metabolism by the intestinal flora. The significance of xenobiotic metabolism by the intestinal microflora is discussed.
AB - The metabolism of four xenobiotics, pentachloromethylthiobenzene, 2 chloro-n-isopropylacetanilide, 2-acetamido-4- (chloromethyl) thiazole and 2,4',5-trichlorobiphenyl, which are known to be metabolized via the mercapturic acid pathway, was examined in germfree and conventional rats. An essential role for the intestinal flora in the metabolism of the above compounds and in the production of certain metabolites was established. Mechanisms for the formation of these latter metabolites from the mercapturates are proposed. These mechanisms involve enterohepatic circulation and metabolism by the intestinal flora. The significance of xenobiotic metabolism by the intestinal microflora is discussed.
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U2 - 10.1080/01635588109513687
DO - 10.1080/01635588109513687
M3 - Article
C2 - 6810318
AN - SCOPUS:0019866378
VL - 2
SP - 224
EP - 231
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 4
ER -