The effect of influenza vaccination on mortality and risk of hospitalization in patients with heart failure: A systematic review and meta-analysis

Sanjay Poudel, Fadi Shehadeh, Ioannis M. Zacharioudakis, Giannoula S. Tansarli, Fainareti N. Zervou, Markos Kalligeros, Robertus Van Aalst, Ayman Chit, Eleftherios Mylonakis

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background. Influenza is a major cause of morbidity and mortality in patients diagnosed with heart failure. The aim of this study was to evaluate the effectiveness of influenza vaccination in this population in terms of reduction in all-cause mortality and rate of hospitalization. Methods. We conducted a systematic review and meta-analysis using PubMed and EMBASE entries from January of 2000 through April 2018. Publication bias was examined using the Egger's regression test. Statistical heterogeneity was examined using the Higgins I2 statistic. Subgroup analyses were performed to examine the effect of vaccination during the influenza and noninfluenza seasons. Results. We identified 8 studies that included a total of 82 354 patients with heart failure. In patients with heart failure who were vaccinated against influenza, we found a reduced risk of all-cause mortality (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.51-0.87). No evidence of publication bias was found, and the effect was more pronounced during influenza season (HR, 0.49; 95% CI, 0.30-0.69), compared with noninfluenza season (HR, 0.79; 95% CI, 0.68-0.89). In terms of heart failure hospitalizations, we did not identify a statistically significant difference between the cohorts (HR, 0.62; 95% CI, 0.00-1.23). Conclusions. Influenza vaccination was associated with a decreased risk of all-cause mortality in patients with heart failure, and this effect was more prominent during the influenza season.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume6
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • All-cause mortality
  • Heart failure
  • Hospitalization
  • Influenza vaccination

ASJC Scopus subject areas

  • Oncology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'The effect of influenza vaccination on mortality and risk of hospitalization in patients with heart failure: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this