Efecto de la embolia con gelfoam en la conductancia vascular y en la presión crítica de cierre en el lóbulo canino aislado.

Translated title of the contribution: The effect of gelfoam embolism in vascular conduction and critical pressure in the isolated canine lobe

M. E. Furuya, E. Lupi-Herrera, E. Correa, A. Quesada, Roberto Barrios, J. Sandoval

Research output: Contribution to journalArticle

Abstract

Pulmonary pressure-flow curves, hemodynamic and blood gas parameters in West's zone II condition were obtained in nine isolated in situ left lower lobes (LLL) before (condition A), and after 15, 30 and 60 minutes of lobar gelfoam embolization (GE) (condition B) in order to know the natural history of this model. After GE a decrease in PaO2 and lobar O2 were noticed (p less than 0.05). Vascular conductance (p less than 0.001) and lobar blood flow decreased (p less than 0.05), accompanied by a significant increase in the inflow (p less than 0.01) and in the mean closing pressures (p less than 0.01). These parameters did not change during the time of observation at condition B. Nor the cardiac output or the minimal closing pressure changed in relation to condition A. LLL angiographic findings showed evidence of arterial occlusion and the pattern of obstruction was not homogeneous. Lobes histology showed occluded arteries of more than 300 micrometers of diameter. We concluded that in this canine model of increased pulmonary vascular resistance, pulmonary vascular conductance and mean closing pressure change, remain stable during 60 minutes after GE allowing us to know the natural history of the preparation. Condition than allow to perform and evaluate other interventions on lung vascular mechanics in the experimental setting of pulmonary embolization.

Translated title of the contributionThe effect of gelfoam embolism in vascular conduction and critical pressure in the isolated canine lobe
Original languageSpanish
Pages (from-to)233-239
Number of pages7
JournalArchivos del Instituto de Cardiologia de Mexico
Volume60
Issue number3
StatePublished - May 1 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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