Abstract
Complex mixtures consist of homocyclic and heterocyclic polycyclic aromatic compounds (PACs) represented by benzo[a]pyrene (BaP) and 7H-dibenzo[c,g]carbazole (DBC), respectively. To exert their biological effects, PACs are metabolized into reactive intermediates, which can form DNA adducts. In this preliminary report, male A/J mice were given a single intraperitoneal injection. Groups of three animals were treated with DBC (2 or 10 mg/kg) or BaP (10 or 100 mg/kg). Mixtures of DBC:BaP were given at doses o 2:10, 2:100, 10:10, or 10:100 mg/kg. DNA adduct levels in lungs collected three days posttreatment were determined by the 32P-postlabeling method. The results indicate that, in the lungs, exposure to mixtures containing more BaP than DBC resulted in the absence of adduct 3 (DBC) and significantly higher total adduct levels. This suggests that BaP is being preferentially metabolized, resulting in less DBC adduction.
Original language | English (US) |
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Pages (from-to) | 893-897 |
Number of pages | 5 |
Journal | Polycyclic Aromatic Compounds |
Volume | 22 |
Issue number | 3-4 |
DOIs | |
State | Published - 2002 |
Keywords
- 7H-dibenzo[c,g]carbazole
- Benzo[a]pyrene
- DNA adducts
- Mixtures
- Polycyclic aromatic compounds (PACs)
- Strain A/J
ASJC Scopus subject areas
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry