The diversity of sex steroid action: Regulation of metabolism by estrogen signaling

Malin Hedengran Faulds, Chunyan Zhao, Karin Dahlman-Wright, Jan Åke Gustafsson

Research output: Contribution to journalReview article

137 Scopus citations

Abstract

The metabolic syndrome is a complex condition characterized by obesity, insulin resistance, decreased high-density lipoproteins, and hypertension associated with high risk of developing type 2 diabetes and cardiovascular disease. A major increase in the incidence of developing metabolic syndrome and related diseases is observed worldwide in association with a change toward a less active lifestyle and increased food consumption. Estrogen and the estrogen receptors (ERs) are well-known regulators of several aspects of metabolism, including glucose and lipid metabolism, and impaired estrogen signaling is associated with the development of metabolic diseases. This review will describe the key effects of estrogen signaling in metabolic and glucose sensing tissues, including the liver, pancreatic β cells, adipose tissue, and skeletal muscle. The impact on metabolic processes of impaired estrogen signaling and knock out of each ER subtype will also be discussed.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalJournal of Endocrinology
Volume212
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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