The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

Lorenz Poellinger, Martin Göttlicher, Jan Åke Gustafsson

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

Dioxins and peroxisome proliferators represent two diverse classes of xenobiotic compounds that induce transcription of specific genes encoding cytochrome P-450 drug-metabolizing enzymes. Signal transduction by these chemicals is mediated by two distinct nuclear receptors, one of which has recently been demonstrated to be a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. However, no endogenous ligand has so far been identified for either of these nuclear receptors. Lorenz Poellinger, Martin Göttlicher and Jan-Åke Gustafsson review properties of both these xenobiotic receptor systems and discuss how the molecular details in the receptor activation pathways compare with those of nuclear hormone receptors.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalTrends in Pharmacological Sciences
Volume13
Issue numberC
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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