TY - JOUR
T1 - The different roles of ER subtypes in cancer biology and therapy
AU - Thomas, Christoforos
AU - Gustafsson, Jan Åke
N1 - Funding Information:
Research in the authors’ laboratory is supported by the Welch Foundation and the Texas Emergency Technology Fund, under Agreement No 300-9-1958.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ER± and ERÎ 2 exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
AB - By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ER± and ERÎ 2 exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
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U2 - 10.1038/nrc3093
DO - 10.1038/nrc3093
M3 - Review article
C2 - 21779010
AN - SCOPUS:79960832381
SN - 1474-175X
VL - 11
SP - 597
EP - 608
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -