The different roles of ER subtypes in cancer biology and therapy

Christoforos Thomas, Jan-Ake Gustafsson

Research output: Contribution to journalReview article

428 Scopus citations

Abstract

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ER± and ERÎ 2 exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.

Original languageEnglish (US)
Pages (from-to)597-608
Number of pages12
JournalNature Reviews Cancer
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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