Abstract
Despite being under development for decades, RNA therapeutics have
only recently emerged as viable drug platforms. The COVID-19 mRNA
vaccines have demonstrated the promise and power of the platform
technology. In response, novel RNA drugs are entering clinical trials at an
accelerating rate. As the skin is the largest and most accessible organ, it has
always been a preferred target for drug discovery. This holds true for RNA
therapies as well, and multiple candidate RNA-based drugs are currently in
development for an array of skin conditions. In this mini review, we catalog
the RNA therapies currently in clinical trials for different dermatological
diseases. We summarize the main types of RNA-related drugs and
use examples of drugs currently in development to illustrate their key
mechanism of action.
only recently emerged as viable drug platforms. The COVID-19 mRNA
vaccines have demonstrated the promise and power of the platform
technology. In response, novel RNA drugs are entering clinical trials at an
accelerating rate. As the skin is the largest and most accessible organ, it has
always been a preferred target for drug discovery. This holds true for RNA
therapies as well, and multiple candidate RNA-based drugs are currently in
development for an array of skin conditions. In this mini review, we catalog
the RNA therapies currently in clinical trials for different dermatological
diseases. We summarize the main types of RNA-related drugs and
use examples of drugs currently in development to illustrate their key
mechanism of action.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4-13 |
| Journal | Journal of Dermatology and Skin Science |
| DOIs | |
| State | Published - May 2023 |