TY - JOUR
T1 - The Cutaneous Manifestations of Sinus Histiocytosis With Massive Lymphadenopathy
AU - Thawerani, Hasina
AU - Sanchez, Ramónl
AU - Rosai, Juan
AU - Dorfman, Ronald F.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1978/2
Y1 - 1978/2
N2 - Ten patients with sinus histiocytosis with massive lymphadenopathy (SHML) also had cutaneous involvement. Seven of the ten were children. The skin lesions were solitary in three patients and multiple in seven. They were papular or nodular, up to 4 cm in diameter, and often had a xanthomatous appearance. Microscopically, they were constituted by a dermal infiltrate made up predominantly of histiocytes, plasma cells, and lymphocytes. Some of the histiocytes contained phagocytosed lymphocytes in their cytoplasm. The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy.
AB - Ten patients with sinus histiocytosis with massive lymphadenopathy (SHML) also had cutaneous involvement. Seven of the ten were children. The skin lesions were solitary in three patients and multiple in seven. They were papular or nodular, up to 4 cm in diameter, and often had a xanthomatous appearance. Microscopically, they were constituted by a dermal infiltrate made up predominantly of histiocytes, plasma cells, and lymphocytes. Some of the histiocytes contained phagocytosed lymphocytes in their cytoplasm. The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy.
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U2 - 10.1001/archderm.1978.01640140009003
DO - 10.1001/archderm.1978.01640140009003
M3 - Article
C2 - 629544
AN - SCOPUS:0017932494
VL - 114
SP - 191
EP - 197
JO - Archives of Dermatology
JF - Archives of Dermatology
SN - 0003-987X
IS - 2
ER -