The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

ALLFTD consortium

doi:10.1002/alz.12494

The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

ALLFTD consortium

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.

METHODS: In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.

RESULTS: Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.

DISCUSSION: Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.

Original language	English (US)
Journal	Alzheimer's and Dementia
DOIs	https://doi.org/10.1002/alz.12494
State	E-pub ahead of print - Dec 2 2021

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10.1002/alz.12494

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@article{0296ed9f1f9d4738a0cb480d632fd3a6,

title = "The contribution of behavioral features to caregiver burden in FTLD spectrum disorders",

abstract = "INTRODUCTION: Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.METHODS: In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.RESULTS: Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.DISCUSSION: Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.",

author = "Silverman, {Hannah E} and Ake, {Jeannie M} and Masood Manoochehri and Appleby, {Brian S} and Danielle Brushaber and Devick, {Katrina L} and Dickerson, {Bradford C} and Fields, {Julie A} and Forsberg, {Leah K} and Nupur Ghoshal and Graff-Radford, {Neill R} and Murray Grossman and Heuer, {Hilary W} and John Kornak and Lapid, {Maria I} and Irene Litvan and Mackenzie, {Ian R} and Mendez, {Mario F} and Onyike, {Chiadi U} and Belen Pascual and Tartaglia, {Maria Carmela} and Boeve, {Bradley F} and Boxer, {Adam L} and Rosen, {Howard J} and Stephanie Cosentino and Huey, {Edward D} and Barker, {Megan S} and Goldman, {Jill S} and {ALLFTD consortium}",

note = "{\textcopyright} 2021 the Alzheimer's Association.",

year = "2021",

month = dec,

day = "2",

doi = "10.1002/alz.12494",

language = "English (US)",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier",

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TY - JOUR

T1 - The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

AU - Silverman, Hannah E

AU - Ake, Jeannie M

AU - Manoochehri, Masood

AU - Appleby, Brian S

AU - Brushaber, Danielle

AU - Devick, Katrina L

AU - Dickerson, Bradford C

AU - Fields, Julie A

AU - Forsberg, Leah K

AU - Ghoshal, Nupur

AU - Graff-Radford, Neill R

AU - Grossman, Murray

AU - Heuer, Hilary W

AU - Kornak, John

AU - Lapid, Maria I

AU - Litvan, Irene

AU - Mackenzie, Ian R

AU - Mendez, Mario F

AU - Onyike, Chiadi U

AU - Pascual, Belen

AU - Tartaglia, Maria Carmela

AU - Boeve, Bradley F

AU - Boxer, Adam L

AU - Rosen, Howard J

AU - Cosentino, Stephanie

AU - Huey, Edward D

AU - Barker, Megan S

AU - Goldman, Jill S

AU - ALLFTD consortium

PY - 2021/12/2

Y1 - 2021/12/2

N2 - INTRODUCTION: Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.METHODS: In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.RESULTS: Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.DISCUSSION: Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.

AB - INTRODUCTION: Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.METHODS: In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.RESULTS: Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.DISCUSSION: Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.

U2 - 10.1002/alz.12494

DO - 10.1002/alz.12494

M3 - Article

C2 - 34854532

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

ER -

The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

Abstract

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