THE CONTRIBUTION OF AXOPLASMIC FLOW IN OPTIC NERVE AND PROTEIN SYNTHESIS WITHIN THE OPTIC TECTUM TO SYNAPTIC MEMBRANE PROTEINS OF THE CHICK OPTIC TECTUM

H. C. Carton, Stanley H. Appel

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In the 5 day old chick, radioactive leucine was incorporated into proteins of synaptosomal and subsynaptosomal fractions both by fast axoplasmic flow and synthesis within the optic tectum. The distribution of radioactivity in subsynaptosomal fractions suggested that both pathways contribute to the protein constituents of each fraction. The relative contributions to each fraction were similar except for the supernatant proteins, for which fast axoplasmic flow contributed less than the synthesis within the optic tectum. The qualitative contribution of fast flow and synthesis within the optic tectum to the synaptic membrane fraction was distinctive. Fast axoplasmic flow preferentially labelled the high molecular weight proteins, whereas synthesis within the optic tectum labelled a larger percentage of smaller molecular weight proteins.

Original languageEnglish (US)
Pages (from-to)1707-1717
Number of pages11
JournalJournal of Neurochemistry
Volume20
Issue number6
DOIs
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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