TY - JOUR
T1 - THE CONTRIBUTION OF AXOPLASMIC FLOW IN OPTIC NERVE AND PROTEIN SYNTHESIS WITHIN THE OPTIC TECTUM TO SYNAPTIC MEMBRANE PROTEINS OF THE CHICK OPTIC TECTUM
AU - Carton, H. C.
AU - Appel, S. H.
PY - 1973/6
Y1 - 1973/6
N2 - In the 5 day old chick, radioactive leucine was incorporated into proteins of synaptosomal and subsynaptosomal fractions both by fast axoplasmic flow and synthesis within the optic tectum. The distribution of radioactivity in subsynaptosomal fractions suggested that both pathways contribute to the protein constituents of each fraction. The relative contributions to each fraction were similar except for the supernatant proteins, for which fast axoplasmic flow contributed less than the synthesis within the optic tectum. The qualitative contribution of fast flow and synthesis within the optic tectum to the synaptic membrane fraction was distinctive. Fast axoplasmic flow preferentially labelled the high molecular weight proteins, whereas synthesis within the optic tectum labelled a larger percentage of smaller molecular weight proteins.
AB - In the 5 day old chick, radioactive leucine was incorporated into proteins of synaptosomal and subsynaptosomal fractions both by fast axoplasmic flow and synthesis within the optic tectum. The distribution of radioactivity in subsynaptosomal fractions suggested that both pathways contribute to the protein constituents of each fraction. The relative contributions to each fraction were similar except for the supernatant proteins, for which fast axoplasmic flow contributed less than the synthesis within the optic tectum. The qualitative contribution of fast flow and synthesis within the optic tectum to the synaptic membrane fraction was distinctive. Fast axoplasmic flow preferentially labelled the high molecular weight proteins, whereas synthesis within the optic tectum labelled a larger percentage of smaller molecular weight proteins.
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U2 - 10.1111/j.1471-4159.1973.tb00286.x
DO - 10.1111/j.1471-4159.1973.tb00286.x
M3 - Article
C2 - 4124178
AN - SCOPUS:0015858169
SN - 0022-3042
VL - 20
SP - 1707
EP - 1717
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 6
ER -